Anti-VDAC3 Antibody (CAB10544)
- SKU:
- CAB10544
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-VDAC3 Antibody |
| 抗体コード: | CAB10544 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC3 (NP_005653.3). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | A-431 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC3 (NP_005653.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MCNT PTYC DLGK AAKD VFNK GYGF GMVK IDLK TKSC SGVE FSTS GHAY TDTG KASG NLET KYKV CNYG LTFT QKWN TDNT LGTE ISWE NKLA EGLK LTLD TIFV PNTG KKSG KLKA SYKR DCFS VGSN VDID FSGP TIYG WAVL AFEG WLAG YQMS FDTA KSKL SQNN FALG YKAA DFQL HTHV NDGT EFGG SIYQ KVNE KIET SINL AWTA GSNN TRFG IAAK YMLD CRTS LSAK VNNA SLIG LGYT QTLR PGVK LTLS ALID GKNF SAGG HKVG LGFE LEA |
| 遺伝子ID: | 7419 |
| Uniprot: | Q9Y277 |
| セルラーロケーション: | Mitochondrion outer membrane |
| 計算された分子量: | 30kDa |
| 観察された分子量: | 31kDa |
| 同義語: | VDAC3, HD-VDAC3, VDAC-3 |
| バックグラウンド: | This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | VDAC3: a protein of the eukaryotic mitochondrial porin family. Forms a voltage-dependent anion channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Channel, misc.; Membrane protein, integral; Mitochondrial Chromosomal Location of Human Ortholog: 8p11.21 Cellular Component: mitochondrion; nucleus Molecular Function:voltage-gated anion channel activity Biological Process: adenine transport |
| NCBI Summary: | This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q9Y277 |
| NCBI GenInfo Identifier: | 12643945 |
| NCBI Gene ID: | 7419 |
| NCBI Accession: | Q9Y277.1 |
| UniProt Secondary Accession: | Q9Y277,Q9UIS0, |
| UniProt Related Accession: | Q9Y277 |
| Molecular Weight: | 31kDa |
| NCBI Full Name: | Voltage-dependent anion-selective channel protein 3 |
| NCBI Synonym Full Names: | voltage dependent anion channel 3 |
| NCBI Official Symbol: | VDAC3 |
| NCBI Official Synonym Symbols: | VDAC-3; HD-VDAC3 |
| NCBI Protein Information: | voltage-dependent anion-selective channel protein 3 |
| UniProt Protein Name: | Voltage-dependent anion-selective channel protein 3 |
| UniProt Synonym Protein Names: | Outer mitochondrial membrane protein porin 3 |
| Protein Family: | Voltage-dependent anion-selective channel protein |
| UniProt Gene Name: | VDAC3 |
 | Western blot analysis of extracts of A-431 cells, using VDAC3 antibody (CAB10544) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunofluorescence analysis of HeLa cells using VDAC3 antibody (CAB10544) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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