Anti-USP19 Antibody (CAB20006)[KO Validated]
![Anti-USP19 Antibody (CAB20006)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/16849/16725/anti-usp19-antibody-cab20006ko-validated__73924__43146.1645803576.jpg?c=1 "Anti-USP19 Antibody (CAB20006)[KO Validated]")
- SKU:
- CAB20006
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
![Anti-USP19 Antibody (CAB20006)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/16849/16725/anti-usp19-antibody-cab20006ko-validated__73924__43146.1645803576.jpg?c=1&imbypass=on "Anti-USP19 Antibody (CAB20006)[KO Validated]")
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Description
| 抗体名: | Anti-USP19 Antibody [KO Validated] |
| 抗体コード: | CAB20006 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human USP19. |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant protein of human USP19. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10869 |
| Uniprot: | O94966 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Single-pass membrane protein |
| 計算された分子量: | 71kDa/140-156kDa |
| 観察された分子量: | 170KDa |
![Anti-USP19 Antibody [KO Validated] (CAB20006)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/j/228/A20006_1__22507.jpg) | Western blot analysis of extracts from normal (control) and USP19 knockout (KO) 293T cells, using USP19 antibody (CAB20006) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | USP19, ZMYND9 |
| バックグラウンド: | Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | USP19: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. Belongs to the peptidase C19 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Ubiquitin-specific protease; Protease; Ubiquitin conjugating system; EC 3.4.19.12 Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: cytosol; endoplasmic reticulum membrane; integral to membrane Molecular Function:Hsp90 protein binding; metal ion binding; protein binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity Biological Process: ER-associated protein catabolic process; negative regulation of skeletal muscle development; protein deubiquitination; protein stabilization; regulation of protein stability |
| UniProt Code: | O94966 |
| NCBI GenInfo Identifier: | 152031724 |
| NCBI Gene ID: | 10869 |
| NCBI Accession: | O94966.2 |
| UniProt Secondary Accession: | O94966,Q3KQW4, Q641Q9, Q6NZY8, Q86XV9, A5PKX8, A6H8U2 B4DGT3, B4DTZ0, E7EN22, E7ETS0, E9PEG8, |
| UniProt Related Accession: | O94966 |
| Molecular Weight: | 150,659 Da |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 19 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 19 |
| NCBI Official Symbol: | USP19 |
| NCBI Official Synonym Symbols: | ZMYND9 |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 19 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 19 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19; Zinc finger MYND domain-containing protein 9 |
| UniProt Gene Name: | USP19 |
| UniProt Entry Name: | UBP19_HUMAN |