Anti-UBA2 Antibody (CAB17342)
- SKU:
- CAB17342
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-UBA2 Antibody |
| 抗体コード: | CAB17342 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-160 of human UBA2 (NP_005490.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-160 of human UBA2 (NP_005490.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QFLF QKKH VGRS KAQV AKES VLQF YPKA NIVA YHDS IMNP DYNV EFFR QFIL VMNA LDNR AARN HVNR MCLA ADVP LIES GTAG YLGQ VTTI KKGV TECY E |
| 遺伝子ID: | 10054 |
| Uniprot: | Q9UBT2 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 60kDa/71kDa |
| 観察された分子量: | 90kDa |
| 同義語: | UBA2, ARX, HRIHFB2115, SAE2 |
| バックグラウンド: |
| UniProt Protein Function: | SAE2: a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 19q12 Cellular Component: nucleoplasm; cytosol; nucleus Molecular Function:SUMO activating enzyme activity; protein binding; protein heterodimerization activity; metal ion binding; enzyme activator activity; transcription factor binding; ATP binding Biological Process: positive regulation of catalytic activity; cellular protein metabolic process; protein sumoylation; SMT3-dependent protein catabolic process; post-translational protein modification |
| NCBI Summary: | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
| UniProt Code: | Q9UBT2 |
| NCBI GenInfo Identifier: | 42559898 |
| NCBI Gene ID: | 10054 |
| NCBI Accession: | Q9UBT2.2 |
| UniProt Secondary Accession: | Q9UBT2,O95605, Q59H87, Q6IBP6, Q9NTJ1, Q9UED2, B3KWB9 |
| UniProt Related Accession: | Q9UBT2 |
| Molecular Weight: | 640 |
| NCBI Full Name: | SUMO-activating enzyme subunit 2 |
| NCBI Synonym Full Names: | ubiquitin-like modifier activating enzyme 2 |
| NCBI Official Symbol: | UBA2 |
| NCBI Official Synonym Symbols: | ARX; SAE2; HRIHFB2115 |
| NCBI Protein Information: | SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog |
| UniProt Protein Name: | SUMO-activating enzyme subunit 2 |
| UniProt Synonym Protein Names: | Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2 |
| Protein Family: | Ubiquitin-activating enzyme |
| UniProt Gene Name: | UBA2 |
| UniProt Entry Name: | SAE2_HUMAN |
 | Western blot analysis of extracts of Rat lung, using UBA2 antibody (CAB17342) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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