Anti-TTPA Antibody (CAB8562)
- SKU:
- CAB8562
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-TTPA Antibody |
| 抗体コード: | CAB8562 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 51-278 of human TTPA (NP_000361.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T, HepG2, DU145 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 51-278 of human TTPA (NP_000361.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FLLR FLRA RDFD LDLA WRLL KNYY KWRA ECPE ISAD LHPR SIIG LLKA GYHG VLRS RDPT GSKV LIYR IAHW DPKV FTAY DVFR VSLI TSEL IVQE VETQ RNGI KAIF DLEG WQFS HAFQ ITPS VAKK IAAV LTDS FPLK VRGI HLIN EPVI FHAV FSMI KPFL TEKI KERI HMHG NNYK QSLL QHFP DILP LEYG GEEF SMED ICQE WTNF IMKS EDYL SSIS ESIQ |
| 遺伝子ID: | 7274 |
| Uniprot: | P49638 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 31kDa |
| 観察された分子量: | 37kDa |
| 同義語: | TTPA, ATTP, AVED, TTP1, alphaTTP |
| バックグラウンド: | This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. |
| UniProt Protein Function: | TTPA: Binds alpha-tocopherol and enhances its transfer between separate membranes. Defects in TTPA are the cause of ataxia with isolated vitamin E deficiency (AVED). AVED is an autosomal recessive disease characterized by spinocerebellar degeneration. It causes ataxia and peripheral neuropathy that resembles Friedreich ataxia. AVED patients have markedly reduced plasma levels of vitamin E. |
| UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 8q12.3 Molecular Function:phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; vitamin E binding Biological Process: intermembrane transport; lipid metabolic process; transport; vitamin transport Disease: Vitamin E, Familial Isolated Deficiency Of |
| NCBI Summary: | This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009] |
| UniProt Code: | P49638 |
| NCBI GenInfo Identifier: | 1351322 |
| NCBI Gene ID: | 7274 |
| NCBI Accession: | P49638.1 |
| UniProt Secondary Accession: | P49638,Q71V64, |
| UniProt Related Accession: | P49638 |
| Molecular Weight: | 32kDa |
| NCBI Full Name: | Alpha-tocopherol transfer protein |
| NCBI Synonym Full Names: | alpha tocopherol transfer protein |
| NCBI Official Symbol: | TTPA |
| NCBI Official Synonym Symbols: | ATTP; AVED; TTP1; alphaTTP |
| NCBI Protein Information: | alpha-tocopherol transfer protein |
| UniProt Protein Name: | Alpha-tocopherol transfer protein |
| Protein Family: | Alpha-tocopherol transfer protein |
| UniProt Gene Name: | TTPA |
 | Western blot analysis of extracts of various cell lines, using TTPA antibody (CAB8562) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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