Anti-STRA6 Antibody (CAB12126)
- SKU:
- CAB12126
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-STRA6 Antibody |
| 抗体コード: | CAB12126 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 538-667 of human STRA6 (NP_071764.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 538-667 of human STRA6 (NP_071764.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LYNA IHLG QMDL SLLP PRAA TLDP GYYT YRNF LKIE VSQS HPAM TAFC SLLL QAQS LLPR TMAA PQDS LRPG EEDE GMQL LQTK DSMA KGAR PGAS RGRA RWGL AYTL LHNP TLQV FRKT ALLG ANGA QP |
| 遺伝子ID: | 64220 |
| Uniprot: | Q9BX79 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 17kDa/72kDa/73kDa/75kDa/77kDa |
| 観察された分子量: | 74kDa |
| 同義語: | STRA6, MCOPCB8, MCOPS9, PP14296 |
| バックグラウンド: | The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. |
| UniProt Protein Function: | STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 15q24.1 Cellular Component: plasma membrane; protein complex Biological Process: adrenal gland development; alveolus development; artery morphogenesis; blood vessel development; cognition; developmental growth; digestive tract morphogenesis; ear development; embryonic gut development; feeding behavior; female genitalia development; heart development; kidney development; learning; lung development; neuromuscular process; nose morphogenesis; positive regulation of behavior; retinoid metabolic process; smooth muscle development; vocal learning Disease: Microphthalmia, Syndromic 9 |
| NCBI Summary: | The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9BX79 |
| NCBI GenInfo Identifier: | 74733466 |
| NCBI Gene ID: | 64220 |
| NCBI Accession: | Q9BX79.1 |
| UniProt Secondary Accession: | Q9BX79,Q6PJF8, Q71RB9, Q7L9G1, Q7Z3U9, Q8TB21, A8K7F1 B7Z5M9, B7Z862, D3DW54, F5GYI8, I3L1G8, |
| UniProt Related Accession: | Q9BX79 |
| Molecular Weight: | 74kDa |
| NCBI Full Name: | Stimulated by retinoic acid gene 6 protein homolog |
| NCBI Synonym Full Names: | stimulated by retinoic acid 6 |
| NCBI Official Symbol: | STRA6 |
| NCBI Official Synonym Symbols: | MCOPS9; MCOPCB8; PP14296 |
| NCBI Protein Information: | stimulated by retinoic acid gene 6 protein homolog |
| UniProt Protein Name: | Stimulated by retinoic acid gene 6 protein homolog |
| Protein Family: | Stimulated by retinoic acid gene 6 protein |
| UniProt Gene Name: | STRA6 |
 | Western blot analysis of extracts of 293T cells, using STRA6 antibody (CAB12126) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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