Anti-SLC4A11 Antibody (CAB15910)
- SKU:
- CAB15910
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC4A11 Antibody |
| 抗体コード: | CAB15910 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC4A11 (NP_114423.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC4A11 (NP_114423.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSQV GGRG DRCT QEVQ GLVH GAGD LSAS LAEN SPTM SQNG YFED SSYY KCDT DDTF EARE EILG DEAF DTAN SSIV SGES IRFF VNVN LEMQ ATNT ENEA TSGG CVLL HTSR KYLK LKNF KEEI RAHR DLDG FLAQ ASIV LNET ATSL DNVL RTML RRFA RDPD NNEP NCNL DLLM AMLF |
| 遺伝子ID: | 83959 |
| Uniprot: | Q8NBS3 |
| セルラーロケーション: | Cell membrane, Membrane, Multi-pass membrane protein |
| 計算された分子量: | 45kDa/98kDa/99kDa/103kDa |
| 観察された分子量: | 100kDa/110kDa |
| 同義語: | SLC4A11, BTR1, CDPD1, CHED, CHED2, NABC1, dJ794I6.2 |
| バックグラウンド: | This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. |
| UniProt Protein Function: | Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na+ and OH-(H+) channel. In the presence of borate functions as an electrogenic Na+ coupled borate cotransporter. |
| NCBI Summary: | This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q8NBS3 |
| NCBI GenInfo Identifier: | 291490688 |
| NCBI Gene ID: | 83959 |
| NCBI Accession: | NP_001167560.1 |
| UniProt Secondary Accession: | Q8NBS3,Q2TB62, Q2TB63, Q9BXF4, Q9NTW9, B4DKC8, B4DKX9 G3V1M3, |
| UniProt Related Accession: | Q8NBS3 |
| Molecular Weight: | 103,145 Da |
| NCBI Full Name: | sodium bicarbonate transporter-like protein 11 isoform 3 |
| NCBI Synonym Full Names: | solute carrier family 4 member 11 |
| NCBI Official Symbol: | SLC4A11 |
| NCBI Official Synonym Symbols: | BTR1; CHED; CDPD1; CHED2; NABC1; dJ794I6.2 |
| NCBI Protein Information: | sodium bicarbonate transporter-like protein 11 |
| UniProt Protein Name: | Sodium bicarbonate transporter-like protein 11 |
| UniProt Synonym Protein Names: | Bicarbonate transporter-related protein 1; Sodium borate cotransporter 1; NaBC1; Solute carrier family 4 member 11 |
| Protein Family: | Protein |
| UniProt Gene Name: | SLC4A11 |
 | Western blot analysis of extracts of various cell lines, using SLC4A11 antibody (CAB15910) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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