Anti-SLC47A1 Antibody (CAB14559)
- SKU:
- CAB14559
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC47A1 Antibody |
| 抗体コード: | CAB14559 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-550 of human SLC47A1 (NP_060712.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 460-550 of human SLC47A1 (NP_060712.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LNWK KACQ QAQV HANL KVNN VPRS GNSA LPQD PLHP GCPE NLEG ILTN DVGK TGEP QSDQ QMRQ EEPL PEHP QDGA KLSR KQLV LRRG LLL |
| 遺伝子ID: | 55244 |
| Uniprot: | Q96FL8 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 31kDa/61kDa/63kDa |
| 観察された分子量: | 62kDa |
| 同義語: | SLC47A1, MATE1 |
| バックグラウンド: | This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. |
| UniProt Protein Function: | SLC47A1: Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter, SLC family; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: integral to membrane; plasma membrane Molecular Function:drug transporter activity; monovalent cation:proton antiporter activity Biological Process: multidrug transport; organic cation transport; transmembrane transport |
| NCBI Summary: | This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96FL8 |
| NCBI GenInfo Identifier: | 22907060 |
| NCBI Gene ID: | 55244 |
| NCBI Accession: | NP_060712.2 |
| UniProt Related Accession: | Q96FL8 |
| Molecular Weight: | Calculated MW: 31kDa/61kDa/63kDaObserved MW: 62kDa |
| NCBI Full Name: | multidrug and toxin extrusion protein 1 |
| NCBI Synonym Full Names: | solute carrier family 47 member 1 |
| NCBI Official Symbol: | SLC47A1 |
| NCBI Official Synonym Symbols: | MATE1 |
| NCBI Protein Information: | multidrug and toxin extrusion protein 1 |
| UniProt Protein Name: | Multidrug and toxin extrusion protein 1 |
| UniProt Synonym Protein Names: | Solute carrier family 47 member 1 |
| Protein Family: | Multidrug and toxin extrusion protein |
| UniProt Gene Name: | SLC47A1 |
| UniProt Entry Name: | S47A1_HUMAN |
 | Western blot analysis of extracts of rat liver, using SLC47A1 antibody (CAB14559) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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