Anti-SLC40A1 Antibody (CAB14885)
- SKU:
- CAB14885
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC40A1 Antibody |
| 抗体コード: | CAB14885 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC40A1 (NP_055400.1). |
| 申し込み: | IHC |
| 推奨希釈: | IHC 1:50 - 1:200 |
| 反応性: | Human, Rat |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC40A1 (NP_055400.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SPVI GCGF ISGW NLVS MCVE YVLL WKVY QKTP ALAV KAGL KEEE TELK QLNL HKDT EPKP LEGT HLMG VKDS NIHE LEHE QEPT CASQ MAEP FRTF RDGW V |
| 遺伝子ID: | 30061 |
| Uniprot: | Q9NP59 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 62kDa |
| 観察された分子量: |
| 同義語: | SLC40A1, FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3 |
| バックグラウンド: | The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). |
| UniProt Protein Function: | SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family Chromosomal Location of Human Ortholog: 2q32 Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular Molecular Function:iron ion transmembrane transporter activity; protein binding Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; lymphocyte homeostasis; transmembrane transport; negative regulation of apoptosis Disease: Hemochromatosis, Type 4 |
| NCBI Summary: | The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NP59 |
| NCBI GenInfo Identifier: | 67633296 |
| NCBI Gene ID: | 30061 |
| NCBI Accession: | AAY78556.1 |
| UniProt Secondary Accession: | Q9NP59,Q6FI62, Q7Z4F8, Q8IVB2, Q9NRL0, |
| UniProt Related Accession: | Q9NP59 |
| Molecular Weight: | 62,542 Da |
| NCBI Full Name: | ferroportin 1 variant I, partial |
| NCBI Synonym Full Names: | solute carrier family 40 (iron-regulated transporter), member 1 |
| NCBI Official Symbol: | SLC40A1 |
| NCBI Official Synonym Symbols: | FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3 |
| NCBI Protein Information: | solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3 |
| UniProt Protein Name: | Solute carrier family 40 member 1 |
| UniProt Synonym Protein Names: | Ferroportin-1; Iron-regulated transporter 1 |
| UniProt Gene Name: | SLC40A1 |
| UniProt Entry Name: | S40A1_HUMAN |
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