Anti-SLC25A12 Antibody (CAB11688)
- SKU:
- CAB11688
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC25A12 Antibody |
| 抗体コード: | CAB11688 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC25A12 (NP_003696.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, U-87MG, B cells, SKOV3, HeLa, Mouse heart, Mouse brain, Mouse liver, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC25A12 (NP_003696.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAVK VQTT KRGD PHEL RNIF LQYA STEV DGER YMTP EDFV QRYL GLYN DPNS NPKI VQLL AGVA DQTK DGLI SYQE FLAF ESVL CAPD SMFI VAFQ LFDK SGNG EVTF ENVK EIFG QTII HHHI PFNW DCEF IRLH FGHN RKKH LNYT EFTQ FLQE LQLE HARQ AFAL KDKS KSGM ISGL |
| 遺伝子ID: | 8604 |
| Uniprot: | O75746 |
| セルラーロケーション: | Mitochondrion inner membrane, Multi-pass membrane protein |
| 計算された分子量: | 62kDa/74kDa |
| 観察された分子量: | 75kDa |
| 同義語: | SLC25A12, AGC1, ARALAR, EIEE39 |
| バックグラウンド: | This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. |
| UniProt Protein Function: | SLC25A12: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle. Defects in SLC25A12 are the cause of global cerebral hypomyelination (GCHM). A disorder with onset in infancy and characterized by severe psychomotor retardation, hypotonia, seizures, hypomyelination of the central nervous system, with the gray matter appearing relatively unaffected. Belongs to the mitochondrial carrier family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion Molecular Function:acidic amino acid transmembrane transporter activity; calcium ion binding; L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity Biological Process: aspartate transport; gluconeogenesis; L-glutamate transport; malate-aspartate shuttle; response to calcium ion Disease: Hypomyelination, Global Cerebral |
| NCBI Summary: | This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | O75746 |
| NCBI GenInfo Identifier: | 206729858 |
| NCBI Gene ID: | 8604 |
| NCBI Accession: | O75746.2 |
| UniProt Secondary Accession: | O75746,Q96AM8, B3KR64, |
| UniProt Related Accession: | O75746 |
| Molecular Weight: | 75kDa |
| NCBI Full Name: | Calcium-binding mitochondrial carrier protein Aralar1 |
| NCBI Synonym Full Names: | solute carrier family 25 member 12 |
| NCBI Official Symbol: | SLC25A12 |
| NCBI Official Synonym Symbols: | AGC1; ARALAR; EIEE39 |
| NCBI Protein Information: | calcium-binding mitochondrial carrier protein Aralar1 |
| UniProt Protein Name: | Calcium-binding mitochondrial carrier protein Aralar1 |
| UniProt Synonym Protein Names: | Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12 |
| UniProt Gene Name: | SLC25A12 |
 | Western blot analysis of extracts of various cell lines, using SLC25A12 antibody (CAB11688) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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