Anti-SLC1A3 Antibody (CAB15722)
- SKU:
- CAB15722
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SLC1A3 Antibody |
| 抗体コード: | CAB15722 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 453-542 of human SLC1A3 (NP_004163.3). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, U-251MG, HeLa, H460, C6, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 453-542 of human SLC1A3 (NP_004163.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IVLT SVGL PTDD ITLI IAVD WFLD RLRT TTNV LGDS LGAG IVEH LSRH ELKN RDVE MGNS VIEE NEMK KPYQ LIAQ DNET EKPI DSET KM |
| 遺伝子ID: | 6507 |
| Uniprot: | P43003 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 55kDa/59kDa |
| 観察された分子量: | 70kDa |
| 同義語: | SLC1A3, EA6, EAAT1, GLAST, GLAST1 |
| バックグラウンド: | This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SLC1A3: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial; Transporter, SLC family; Transporter Chromosomal Location of Human Ortholog: 5p13 Cellular Component: membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity Biological Process: glutamate secretion; ion transport; L-glutamate import; neurotransmitter uptake; positive regulation of defense response to virus by host; synaptic transmission Disease: Episodic Ataxia, Type 6 |
| NCBI Summary: | This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014] |
| UniProt Code: | P43003 |
| NCBI GenInfo Identifier: | 262359914 |
| NCBI Gene ID: | 6507 |
| NCBI Accession: | NP_001160167.1 |
| UniProt Secondary Accession: | P43003,Q4JCQ8, B2R5T3, |
| UniProt Related Accession: | P43003 |
| Molecular Weight: | |
| NCBI Full Name: | excitatory amino acid transporter 1 isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 1 member 3 |
| NCBI Official Symbol: | SLC1A3 |
| NCBI Official Synonym Symbols: | EA6; EAAT1; GLAST; GLAST1 |
| NCBI Protein Information: | excitatory amino acid transporter 1 |
| UniProt Protein Name: | Excitatory amino acid transporter 1 |
| UniProt Synonym Protein Names: | Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 |
| Protein Family: | Excitatory amino acid transporter |
| UniProt Gene Name: | SLC1A3 |
| UniProt Entry Name: | EAA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC1A3 antibody (CAB15722) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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