Anti-RXFP1 Antibody (CAB7127)
- SKU:
- CAB7127
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-RXFP1 Antibody |
| 抗体コード: | CAB7127 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 673-757 of human RXFP1 (NP_067647.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HeLa, Mouse brain, Rat brain, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 673-757 of human RXFP1 (NP_067647.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NSAL NPIL YTLT TRPF KEMI HRFW YNYR QRKS MDSK GQKT YAPS FIWV EMWP LQEM PPEL MKPD LFTY PCEM SLIS QSTR LNSY S |
| 遺伝子ID: | 59350 |
| Uniprot: | Q9HBX9 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 21kDa/75kDa/81kDa/83kDa/86kDa |
| 観察された分子量: | 87kDa |
| 同義語: | RXFP1, LGR7, RXFPR1 |
| バックグラウンド: | This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | RXFP1: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. Belongs to the G-protein coupled receptor 1 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 4q32.1 Cellular Component: plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; protein binding; metal ion binding Biological Process: G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9HBX9 |
| NCBI GenInfo Identifier: | 166209887 |
| NCBI Gene ID: | 59350 |
| NCBI Accession: | Q9HBX9.2 |
| UniProt Secondary Accession: | Q9HBX9,Q2M215, Q3KU24, Q3KU25, Q3KU26, B4DHD1, B4DTV2 |
| UniProt Related Accession: | Q9HBX9 |
| Molecular Weight: | 757 |
| NCBI Full Name: | Relaxin receptor 1 |
| NCBI Synonym Full Names: | relaxin/insulin-like family peptide receptor 1 |
| NCBI Official Symbol: | RXFP1 |
| NCBI Official Synonym Symbols: | LGR7; RXFPR1 |
| NCBI Protein Information: | relaxin receptor 1; leucine-rich repeat-containing G protein-coupled receptor 7 |
| UniProt Protein Name: | Relaxin receptor 1 |
| UniProt Synonym Protein Names: | Leucine-rich repeat-containing G-protein coupled receptor 7; Relaxin family peptide receptor 1 |
| Protein Family: | Relaxin receptor |
| UniProt Gene Name: | RXFP1 |
| UniProt Entry Name: | RXFP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RXFP1 antibody (CAB7127) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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