Anti-RCVRN Antibody (CAB6404)
- SKU:
- CAB6404
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-RCVRN Antibody |
| 抗体コード: | CAB6404 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RCVRN (NP_002894.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse eye, Rat eye |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RCVRN (NP_002894.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGNS KSGA LSKE ILEE LQLN TKFS EEEL CSWY QSFL KDCP TGRI TQQQ FQSI YAKF FPDT DPKA YAQH VFRS FDSN LDGT LDFK EYVI ALHM TTAG KTNQ KLEW AFSL YDVD GNGT ISKN EVLE IVMA IFKM ITPE DVKL LPDD ENTP EKRA EKIW KYFG KNDD DKLT EKEF IEGT LANK EILR LIQF EPQK VKEK MKNA |
| 遺伝子ID: | 5957 |
| Uniprot: | P35243 |
| セルラーロケーション: | |
| 計算された分子量: | 23kDa |
| 観察された分子量: | 23kDa |
| 同義語: | RCVRN, RCV1, recoverin |
| バックグラウンド: | This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. |
| UniProt Protein Function: | RCV1: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse. Belongs to the recoverin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 17p13.1 Molecular Function:calcium ion binding; calcium sensitive guanylate cyclase activator activity Biological Process: phototransduction, visible light; positive regulation of guanylate cyclase activity; regulation of calcium ion transport; regulation of rhodopsin mediated signaling; rhodopsin mediated signaling; signal transduction; visual perception |
| NCBI Summary: | This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35243 |
| NCBI GenInfo Identifier: | 464600 |
| NCBI Gene ID: | 5957 |
| NCBI Accession: | P35243.2 |
| UniProt Secondary Accession: | P35243,Q53XL0, |
| UniProt Related Accession: | P35243 |
| Molecular Weight: | 23,130 Da |
| NCBI Full Name: | Recoverin |
| NCBI Synonym Full Names: | recoverin |
| NCBI Official Symbol: | RCVRN |
| NCBI Official Synonym Symbols: | RCV1 |
| NCBI Protein Information: | recoverin |
| UniProt Protein Name: | Recoverin |
| UniProt Synonym Protein Names: | Cancer-associated retinopathy protein; Protein CAR |
| Protein Family: | Recoverin |
| UniProt Gene Name: | RCVRN |
| UniProt Entry Name: | RECO_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RCVRN antibody (CAB6404) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
 | Immunohistochemistry of paraffin-embedded rat retina using RCVRN antibody (CAB6404) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse retina using RCVRN antibody (CAB6404) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of Y79 cells using RCVRN antibody (CAB6404) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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