Anti-NYX Antibody (CAB7830)
- SKU:
- CAB7830
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-NYX Antibody |
| 抗体コード: | CAB7830 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-481 of human NYX (NP_072089.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 282-481 of human NYX (NP_072089.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LLYL DRNS IAFV EEGA FQNL SGLL ALHL NGNR LTVL AWVA FQPG FFLG RLFL FRNP WCCD CRLE WLRD WMEG SGRV TDVP CASP GSVA GLDL SQVT FGRS SDGL CVDP EELN LTTS SPGP SPEP AATT VSRF SSLL SKLL APRV PVEE AANT TGGL ANAS LSDS LSSR GVGG AGRQ PWFL LASC LLPS VAQH VVFG LQMD |
| 遺伝子ID: | 60506 |
| Uniprot: | Q9GZU5 |
| セルラーロケーション: | Secreted, extracellular matrix, extracellular space |
| 計算された分子量: | 52kDa |
| 観察された分子量: | 52kDa |
| 同義語: | NYX, CLRP, CSNB1, CSNB1A, CSNB4, NBM1 |
| バックグラウンド: | The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. |
| UniProt Protein Function: | NYX: Defects in NYX are the cause of congenital stationary night blindness type 1A (CSNB1A); also called X- linked congenital stationary night blindness (XLCSNB). Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNB1A is characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: cytoplasm; intracellular; proteinaceous extracellular matrix Molecular Function:protein kinase inhibitor activity Biological Process: cytokine-mediated signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; visual perception Disease: Night Blindness, Congenital Stationary, Type 1a |
| UniProt Code: | Q9GZU5 |
| NCBI GenInfo Identifier: | 12007646 |
| NCBI Gene ID: | |
| NCBI Accession: | NP_072089.1 |
| Molecular Weight: | 52kDa |
| NCBI Full Name: | nyctalopin |
| UniProt Protein Name: | Nyctalopin |
| Protein Family: | Nyctalopin |
| UniProt Gene Name: | NYX |
 | Western blot analysis of extracts of 293T cells, using NYX antibody (CAB7830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human prostate using NYX antibody (CAB7830) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using NYX antibody (CAB7830) at dilution of 1:100 (40x lens). |
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