Anti-NR2E3 Antibody (CAB6234)
- SKU:
- CAB6234
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-NR2E3 Antibody |
| 抗体コード: | CAB6234 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-410 of human NR2E3 (NP_055064.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, Raji, Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 121-410 of human NR2E3 (NP_055064.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ERQP RSTA QVHL DSME SNTE SRPE SLVA PPAP AGRS PRGP TPMS AARA LGHH FMAS LITA ETCA KLEP EDAD ENID VTSN DPEF PSSP YSSS SPCG LDSI HETS ARLL FMAV KWAK NLPV FSSL PFRD QVIL LEEA WSEL FLLG AIQW SLPL DSCP LLAP PEAS AAGG AQGR LTLA SMET RVLQ ETIS RFRA LAVD PTEF ACMK ALVL FKPE TRGL KDPE HVEA LQDQ SQVM LSQH SKAH HPSQ PVRF GKLL LLLP SLRF ITAE RIEL LFFR KTIG NTPM EKLL CDMF KN |
| 遺伝子ID: | 10002 |
| Uniprot: | Q9Y5X4 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 39kDa/44kDa |
| 観察された分子量: | 45kDa |
| 同義語: | NR2E3, ESCS, PNR, RNR, RP37, rd7 |
| バックグラウンド: | This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | NR2E3: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS). ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration. Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor Chromosomal Location of Human Ortholog: 15q23 Cellular Component: nucleoplasm; transcription factor complex; nucleus Molecular Function:protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; positive regulation of rhodopsin gene expression; negative regulation of transcription from RNA polymerase II promoter; signal transduction; negative regulation of cell proliferation; eye photoreceptor cell development; visual perception; retina development in camera-type eye; phototransduction; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling Disease: Retinitis Pigmentosa 37; Enhanced S-cone Syndrome |
| NCBI Summary: | This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5X4 |
| NCBI GenInfo Identifier: | 8928275 |
| NCBI Gene ID: | 10002 |
| NCBI Accession: | Q9Y5X4.1 |
| UniProt Secondary Accession: | Q9Y5X4,Q9UHM4, B6ZGU0, |
| UniProt Related Accession: | Q9Y5X4 |
| Molecular Weight: | 410 |
| NCBI Full Name: | Photoreceptor-specific nuclear receptor |
| NCBI Synonym Full Names: | nuclear receptor subfamily 2, group E, member 3 |
| NCBI Official Symbol: | NR2E3 |
| NCBI Official Synonym Symbols: | PNR; RNR; rd7; ESCS; RP37 |
| NCBI Protein Information: | photoreceptor-specific nuclear receptor; retina-specific nuclear receptor |
| UniProt Protein Name: | Photoreceptor-specific nuclear receptor |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 2 group E member 3; Retina-specific nuclear receptor |
| Protein Family: | Photoreceptor-specific nuclear receptor |
| UniProt Gene Name: | NR2E3 |
| UniProt Entry Name: | NR2E3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NR2E3 antibody (CAB6234) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
View AllClose