Anti-NEURL2 Antibody (CAB14450)
- SKU:
- CAB14450
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-NEURL2 Antibody |
| 抗体コード: | CAB14450 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-285 of human NEURL2 (NP_542787.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, Mouse skeletal muscle, Mouse heart, Mouse brain, Rat skeletal muscle, Rat heart, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-285 of human NEURL2 (NP_542787.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LPPT ARRS RLGV LFCP RPDG TADM HIII NGED MGPS ARGL PAAQ PLYA VVDV FAST KSVR LVQL EYGL PSLQ TLCR LVIQ RSMV HRLA IDGL HLPK ELKD FCKY E |
| 遺伝子ID: | 140825 |
| Uniprot: | Q9BR09 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 31kDa |
| 観察された分子量: | 32kDa |
| 同義語: | NEURL2, C20orf163, OZZ, OZZ-E3 |
| バックグラウンド: | This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | NEURL2: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.- Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: muscle tendon junction; VCB complex Biological Process: protein ubiquitination; sarcomere organization |
| NCBI Summary: | This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
| UniProt Code: | Q9BR09 |
| NCBI GenInfo Identifier: | 33301415 |
| NCBI Gene ID: | |
| NCBI Accession: | Q9BR09.1 |
| UniProt Secondary Accession: | Q9BR09,Q3KR34, |
| Molecular Weight: | 31,690 Da |
| NCBI Full Name: | Neuralized-like protein 2 |
| UniProt Protein Name: | Neuralized-like protein 2 |
| Protein Family: | Neuralized-like protein |
| UniProt Gene Name: | NEURL2 |
| UniProt Entry Name: | NEUL2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using NEURL2 antibody (CAB14450) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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