Anti-MTCH2 Antibody (CAB19922)[KO Validated]
![Anti-MTCH2 Antibody (CAB19922)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/18559/18425/anti-mtch2-antibody-cab19922ko-validated__90042__23360.1645803991.jpg?c=1 "Anti-MTCH2 Antibody (CAB19922)[KO Validated]")
- SKU:
- CAB19922
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
![Anti-MTCH2 Antibody (CAB19922)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/18559/18425/anti-mtch2-antibody-cab19922ko-validated__90042__23360.1645803991.jpg?c=1&imbypass=on "Anti-MTCH2 Antibody (CAB19922)[KO Validated]")
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Description
| 抗体名: | Anti-MTCH2 Antibody [KO Validated] |
| 抗体コード: | CAB19922 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human MTCH2. |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:1000 - 1:3000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant protein of human MTCH2. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 23788 |
| Uniprot: | Q9Y6C9 |
| セルラーロケーション: | Mitochondrion inner membrane, Multi-pass membrane protein |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 33KDa |
![Anti-MTCH2 Antibody [KO Validated] (CAB19922)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/x/473/A19922_1__01691.jpg) | Western blot analysis of extracts from normal (control) and MTCH2 knockout (KO) 293T cells, using MTCH2 antibody (CAB19922) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
| 同義語: | MTCH2, HSPC032, MIMP, SLC25A50 |
| バックグラウンド: | This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. |
| UniProt Protein Function: | MTCH2: The substrate transported is not yet known. Induces mitochondrial depolarization. Belongs to the mitochondrial carrier family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: membrane; mitochondrion; nucleus Biological Process: positive regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9Y6C9 |
| NCBI GenInfo Identifier: | 67461088 |
| NCBI Gene ID: | 23788 |
| NCBI Accession: | Q9Y6C9.1 |
| UniProt Secondary Accession: | Q9Y6C9,B2R7L8, |
| UniProt Related Accession: | Q9Y6C9 |
| Molecular Weight: | 33kDa |
| NCBI Full Name: | Mitochondrial carrier homolog 2 |
| NCBI Synonym Full Names: | mitochondrial carrier 2 |
| NCBI Official Symbol: | MTCH2 |
| NCBI Official Synonym Symbols: | MIMP; HSPC032; SLC25A50 |
| NCBI Protein Information: | mitochondrial carrier homolog 2 |
| UniProt Protein Name: | Mitochondrial carrier homolog 2 |
| UniProt Synonym Protein Names: | Met-induced mitochondrial protein |
| Protein Family: | Mitochondrial carrier |
| UniProt Gene Name: | MTCH2 |