Anti-MTCH2 Antibody (CAB12934)
- SKU:
- CAB12934
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-MTCH2 Antibody |
| 抗体コード: | CAB12934 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-175 of human MTCH2 (NP_055157.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:1000 - 1:3000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2, HeLa, 293T, HT-29, Mouse small intestine, Mouse brain, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-175 of human MTCH2 (NP_055157.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VGYE PLPP TIGR NIFG RQVC QLPG LFSY AQHI ASID GRRG LFTG LTPR LCSG VLGT VVHG KVLQ HYQE SDKG EELG PGNV QKEV SSSF DHVI KETT REMI ARSA ATLI THPF HVIT LRSM VQFI GRES KYCG LCDS IITI YREE GI |
| 遺伝子ID: | 23788 |
| Uniprot: | Q9Y6C9 |
| セルラーロケーション: | Mitochondrion inner membrane, Multi-pass membrane protein |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 33kDa |
| 同義語: | MTCH2, HSPC032, MIMP, SLC25A50 |
| バックグラウンド: | This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. |
| UniProt Protein Function: | MTCH2: The substrate transported is not yet known. Induces mitochondrial depolarization. Belongs to the mitochondrial carrier family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: membrane; mitochondrion; nucleus Biological Process: positive regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA can give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9Y6C9 |
| NCBI GenInfo Identifier: | 67461088 |
| NCBI Gene ID: | 23788 |
| NCBI Accession: | Q9Y6C9.1 |
| UniProt Secondary Accession: | Q9Y6C9,B2R7L8, |
| UniProt Related Accession: | Q9Y6C9 |
| Molecular Weight: | 33kDa |
| NCBI Full Name: | Mitochondrial carrier homolog 2 |
| NCBI Synonym Full Names: | mitochondrial carrier 2 |
| NCBI Official Symbol: | MTCH2 |
| NCBI Official Synonym Symbols: | MIMP; HSPC032; SLC25A50 |
| NCBI Protein Information: | mitochondrial carrier homolog 2 |
| UniProt Protein Name: | Mitochondrial carrier homolog 2 |
| UniProt Synonym Protein Names: | Met-induced mitochondrial protein |
| Protein Family: | Mitochondrial carrier |
| UniProt Gene Name: | MTCH2 |
 | Western blot analysis of extracts of various cell lines, using MTCH2 antibody (CAB12934) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of NIH-3T3 cells using MTCH2 Polyclonal Antibody (CAB12934) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using MTCH2 Polyclonal Antibody (CAB12934) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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