Anti-MCT1/SLC16A1 Antibody (CAB3013)
- SKU:
- CAB3013
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-MCT1/SLC16A1 Antibody |
| 抗体コード: | CAB3013 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human MCT1 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:1000 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29 |
| 免疫原: | A synthetic peptide of human MCT1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 6566 |
| Uniprot: | P53985 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 46kDa/53kDa |
| 観察された分子量: | 46kDa |
| 同義語: | SLC16A1, HHF7, MCT, MCT1, MCT1D |
| バックグラウンド: | The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | MCT1: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT); also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. Defects in SLC16A1 are the cause of familial hyperinsulinemic hypoglycemia type 7 (HHF7); also known as exercise-induced hyperinsulinemic hypoglycemia. HHF7 is a dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Mitochondrial Chromosomal Location of Human Ortholog: 1p12 Cellular Component: centrosome; membrane; mitochondrion; integral to plasma membrane; integral to membrane; plasma membrane Molecular Function:mevalonate transmembrane transporter activity; protein homodimerization activity; monocarboxylic acid transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity Biological Process: response to food; monocarboxylic acid transport; glucose homeostasis; cellular metabolic process; centrosome organization and biogenesis; mevalonate transport; lipid metabolic process; pyruvate metabolic process; blood coagulation; leukocyte migration; transmembrane transport; regulation of insulin secretion; behavioral response to nutrient Disease: Erythrocyte Lactate Transporter Defect; Monocarboxylate Transporter 1 Deficiency; Hyperinsulinemic Hypoglycemia, Familial, 7 |
| NCBI Summary: | The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009] |
| UniProt Code: | P53985 |
| NCBI GenInfo Identifier: | 313104214 |
| NCBI Gene ID: | 6566 |
| NCBI Accession: | P53985.3 |
| UniProt Secondary Accession: | P53985,Q49A45, Q5T8R6, Q9NSJ9, |
| UniProt Related Accession: | P53985 |
| Molecular Weight: | 46,234 Da |
| NCBI Full Name: | Monocarboxylate transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 16 (monocarboxylate transporter), member 1 |
| NCBI Official Symbol: | SLC16A1 |
| NCBI Official Synonym Symbols: | MCT; HHF7; MCT1 |
| NCBI Protein Information: | monocarboxylate transporter 1; MCT 1; solute carrier family 16 member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1) |
| UniProt Protein Name: | Monocarboxylate transporter 1 |
| UniProt Synonym Protein Names: | Solute carrier family 16 member 1 |
| Protein Family: | Monocarboxylate transporter |
| UniProt Gene Name: | SLC16A1 |
| UniProt Entry Name: | MOT1_HUMAN |
 | Western blot analysis of extracts of HT-29 cells, using MCT1/SLC16A1 antibody (CAB3013) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat pancreas using MCT1/SLC16A1 antibody (CAB3013) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using MCT1/SLC16A1 antibody (CAB3013) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using MCT1/SLC16A1 antibody (CAB3013) at dilution of 1:100 (40x lens). |
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