Anti-LNX1 Antibody (CAB6481)
- SKU:
- CAB6481
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-LNX1 Antibody |
| 抗体コード: | CAB6481 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LNX1 (NP_001119800.1). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:100 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LNX1 (NP_001119800.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNQP ESAN DPEP LCAV CGQA HSLE ENHF YSYP EEVD DDLI CHIC LQAL LDPL DTPC GHTY CTLC LTNF LVEK DFCP MDRK PLVL QHCK KSSI LVNK LLNK LLVT CPFR EHCT QVLQ RCDL EHHF QTSC KGAS HYGL TKDR KRRS QDGC PDGC ASLT ATAP SPEV SAAA TISL MTDE PGLD NPAY VSSA EDGQ PAIS PVDS GRSN RTRA RPFE RSTI RSRS FKKI NRAL SVLR RTKS GSAV ANHA DQGR ENSE NTTA PEVF PRLY HLIP DG |
| 遺伝子ID: | 84708 |
| Uniprot: | Q8TBB1 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 69kDa/80kDa |
| 観察された分子量: |
| 同義語: | LNX1, LNX, MPDZ, PDZRN2 |
| バックグラウンド: | This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. |
| UniProt Protein Function: | LNX1: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.-; Ubiquitin ligase; Adaptor/scaffold; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 4q12 Cellular Component: cytoplasm Molecular Function:protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity; PDZ domain binding Biological Process: protein ubiquitination during ubiquitin-dependent protein catabolic process; protein homooligomerization |
| NCBI Summary: | This gene encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TBB1 |
| NCBI GenInfo Identifier: | 29840786 |
| NCBI Gene ID: | 84708 |
| NCBI Accession: | Q8TBB1.1 |
| UniProt Secondary Accession: | Q8TBB1,Q4W5K7, Q8N4C2, Q96MJ7, Q9BY20, |
| UniProt Related Accession: | Q8TBB1 |
| Molecular Weight: | 728 |
| NCBI Full Name: | E3 ubiquitin-protein ligase LNX |
| NCBI Synonym Full Names: | ligand of numb-protein X 1, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | LNX1 |
| NCBI Official Synonym Symbols: | LNX; MPDZ; PDZRN2 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase LNX; numb-binding protein 1; PDZ domain-containing ring finger protein 2; multi-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX |
| UniProt Protein Name: | E3 ubiquitin-protein ligase LNX |
| UniProt Synonym Protein Names: | Ligand of Numb-protein X 1; Numb-binding protein 1; PDZ domain-containing RING finger protein 2 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | LNX1 |
| UniProt Entry Name: | LNX1_HUMAN |
 | Immunofluorescence analysis of U2OS cells using LNX1 antibody (CAB6481). Blue: DAPI for nuclear staining. |
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