Anti-LAMP2a Antibody (CAB0593)
- SKU:
- CAB0593
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Autophagy
Frequently bought together:
Description
| 抗体名: | Anti-LAMP2a Antibody |
| 抗体コード: | CAB0593 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human LAMP2a |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, Mouse liver, Mouse kidney, Rat liver, Rat kidney |
| 免疫原: | A synthesized peptide derived from human LAMP2a |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3920 |
| Uniprot: | P13473 |
| セルラーロケーション: | |
| 計算された分子量: | 120kDa |
| 観察された分子量: | 100KDa |
 | Western blot - LAMP2a Rabbit mAb (CAB0593) |
| 同義語: | CD107b, LAMP-2, LAMPB, LGP-96, LGP110 |
| バックグラウンド: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xq24 Cellular Component: phagocytic vesicle membrane; membrane; lysosome; lysosomal membrane; late endosome membrane; late endosome; plasma membrane; integral to membrane; platelet dense granule membrane Molecular Function:protein domain specific binding; enzyme binding Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation Disease: Danon Disease |
| NCBI Summary: | The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P13473 |
| NCBI GenInfo Identifier: | 1708854 |
| NCBI Gene ID: | 3920 |
| NCBI Accession: | P13473.2 |
| UniProt Secondary Accession: | P13473,Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93, A8K4X5 D3DTF0, |
| UniProt Related Accession: | P13473 |
| Molecular Weight: | 410 |
| NCBI Full Name: | Lysosome-associated membrane glycoprotein 2 |
| NCBI Synonym Full Names: | lysosomal-associated membrane protein 2 |
| NCBI Official Symbol: | LAMP2 |
| NCBI Official Synonym Symbols: | LAMPB; CD107b; LAMP-2; LGP110 |
| NCBI Protein Information: | lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B |
| UniProt Protein Name: | Lysosome-associated membrane glycoprotein 2 |
| UniProt Synonym Protein Names: | CD107 antigen-like family member B; CD_antigen: CD107b |
| Protein Family: | Lysosome-associated membrane glycoprotein |
| UniProt Gene Name: | LAMP2 |
| UniProt Entry Name: | LAMP2_HUMAN |