Anti-KLHL7 Antibody (CAB7817)
- SKU:
- CAB7817
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-KLHL7 Antibody |
| 抗体コード: | CAB7817 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human KLHL7 (NP_061334.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human KLHL7 (NP_061334.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QAEP LIQD NPEC LKMV ISGM RYHL LSPE DREE LVDG TRPR RKKH DYRI ALFG GSQP QSCR YFNP KDYS WTDI RCPF EKRR DAAC VFWD NVVY ILGG SQLF P |
| 遺伝子ID: | 55975 |
| Uniprot: | Q8IXQ5 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 16kDa/18kDa/60kDa/63kDa/65kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | KLHL7, CISS3, KLHL6, SBBI26 |
| バックグラウンド: | This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. |
| UniProt Protein Function: | KLHL7: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Defects in KLHL7 are the cause of retinitis pigmentosa type 42 (RP42). A retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7p15.3 Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane Molecular Function:identical protein binding; protein binding; protein homodimerization activity; ubiquitin-protein ligase activity Biological Process: protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process Disease: Retinitis Pigmentosa 42 |
| NCBI Summary: | This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010] |
| UniProt Code: | Q8IXQ5 |
| NCBI GenInfo Identifier: | 24660413 |
| NCBI Gene ID: | 55975 |
| NCBI Accession: | BC039585 |
| UniProt Secondary Accession: | Q8IXQ5,Q7Z765, Q96MV2, Q9BQF8, Q9UDQ9, A4D144, B7Z5I9 G5E9G3, |
| UniProt Related Accession: | Q8IXQ5 |
| Molecular Weight: | 60,725 Da |
| NCBI Full Name: | Homo sapiens kelch-like 7 (Drosophila), mRNA |
| NCBI Synonym Full Names: | kelch like family member 7 |
| NCBI Official Symbol: | KLHL7 |
| NCBI Official Synonym Symbols: | CISS3; KLHL6; SBBI26 |
| NCBI Protein Information: | kelch-like protein 7 |
| UniProt Protein Name: | Kelch-like protein 7 |
| Protein Family: | Kelch-like protein |
| UniProt Gene Name: | KLHL7 |
| UniProt Entry Name: | KLHL7_HUMAN |
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