| バックグラウンド: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. |
| NCBI Summary: | Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q13303 |
| NCBI GenInfo Identifier: | 18202496 |
| NCBI Gene ID: | 8514 |
| NCBI Accession: | Q13303.2 |
| UniProt Related Accession: | Q13303 |
| Molecular Weight: | 33kDa; 39kDa; 41kDa; 43kDa; 46kDa |
| NCBI Full Name: | Voltage-gated potassium channel subunit beta-2 |
| NCBI Synonym Full Names: | potassium voltage-gated channel subfamily A regulatory beta subunit 2 |
| NCBI Official Symbol: | KCNAB2 |
| NCBI Official Synonym Symbols: | AKR6A5; KCNA2B; HKvbeta2; KV-BETA-2; HKvbeta2.1; HKvbeta2.2 |
| NCBI Protein Information: | voltage-gated potassium channel subunit beta-2 |
| UniProt Protein Name: | Voltage-gated potassium channel subunit beta-2 |
| UniProt Synonym Protein Names: | K(+) channel subunit beta-2; Kv-beta-2 |
| Protein Family: | Voltage-gated potassium channel |
| UniProt Gene Name: | KCNAB2 |
| UniProt Entry Name: | KCAB2_HUMAN |
