Anti-KCNA4 Antibody (CAB16390)
- SKU:
- CAB16390
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-KCNA4 Antibody |
| 抗体コード: | CAB16390 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human KCNA4 (NP_002224.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Rat brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human KCNA4 (NP_002224.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DIFT EEVK FYQL GEEA LLKF REDE GFVR EEED RALP ENEF KKQI WLLF EYPE SSSP ARGI AIVS VLVI LISI VIFC LETL PEFR DDRD LVMA LSAG GHGG L |
| 遺伝子ID: | 3739 |
| Uniprot: | P22459 |
| セルラーロケーション: | Cell membrane, Cell projection, Multi-pass membrane protein, axon |
| 計算された分子量: | 73kDa |
| 観察された分子量: | 71kDa |
| 同義語: | KCNA4, HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2 |
| バックグラウンド: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential. |
| UniProt Protein Function: | Kv1.4: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily. |
| UniProt Protein Details: | Protein type:Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11p14 Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; axon; plasma membrane; integral to membrane Molecular Function:potassium ion binding; voltage-gated potassium channel activity; protein binding; delayed rectifier potassium channel activity Biological Process: synaptic transmission; potassium ion transport; protein homooligomerization |
| NCBI Summary: | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P22459 |
| NCBI GenInfo Identifier: | 313104127 |
| NCBI Gene ID: | 3739 |
| NCBI Accession: | P22459.2 |
| UniProt Related Accession: | P22459 |
| Molecular Weight: | 73,257 Da |
| NCBI Full Name: | Potassium voltage-gated channel subfamily A member 4 |
| NCBI Synonym Full Names: | potassium voltage-gated channel, shaker-related subfamily, member 4 |
| NCBI Official Symbol: | KCNA4 |
| NCBI Official Synonym Symbols: | HK1; HBK4; PCN2; HPCN2; HUKII; KCNA8; KV1.4; KCNA4L |
| NCBI Protein Information: | potassium voltage-gated channel subfamily A member 4; potassium channel 2; type A potassium channel; cardiac potassium channel; voltage-gated K(+) channel HuKII; voltage-gated potassium channel HK1; voltage-gated potassium channel HBK4; rapidly inactivating potassium channel; shaker-related potassium channel Kv1.4; fetal skeletal muscle potassium channel; voltage-gated potassium channel subunit Kv1.4 |
| UniProt Protein Name: | Potassium voltage-gated channel subfamily A member 4 |
| UniProt Synonym Protein Names: | HPCN2; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4 |
| Protein Family: | Potassium voltage-gated channel subfamily |
| UniProt Gene Name: | KCNA4 |
| UniProt Entry Name: | KCNA4_HUMAN |
 | Western blot analysis of extracts of Rat brain, using KCNA4 Rabbit pAb (CAB16390) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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