Anti-HTR3A Antibody (CAB5647)
- SKU:
- CAB5647
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-HTR3A Antibody |
| 抗体コード: | CAB5647 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-241 of human HTR3A (NP_000860.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Mouse brain, Mouse testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-241 of human HTR3A (NP_000860.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LAQG EARR SRNT TRPA LLRL SDYL LTNY RKGV RPVR DWRK PTTV SIDV IVYA ILNV DEKN QVLT TYIW YRQY WTDE FLQW NPED FDNI TKLS IPTD SIWV PDIL INEF VDVG KSPN IPYV YIRH QGEV QNYK PLQV VTAC SLDI YNFP FDVQ NCSL TFTS WLHT IQDI NISL WRLP EKVK SDRS VFMN QGEW ELLG VLPY FREF SMES SNYY AEMK FY |
| 遺伝子ID: | 3359 |
| Uniprot: | P46098 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 53kDa/55kDa/58kDa/59kDa |
| 観察された分子量: | 55kDa |
| 同義語: | HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 |
| バックグラウンド: | The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | 5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass; Channel, cation; Channel, ligand-gated Chromosomal Location of Human Ortholog: 11q23.1 Cellular Component: postsynaptic membrane; cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; cell junction Molecular Function:serotonin binding; serotonin-activated cation-selective channel activity; voltage-gated potassium channel activity; serotonin receptor activity; receptor activity Biological Process: synaptic transmission; response to ethanol; transport; digestion; response to cocaine; transmembrane transport; serotonin receptor signaling pathway |
| NCBI Summary: | The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P46098 |
| NCBI GenInfo Identifier: | 1168222 |
| NCBI Gene ID: | 3359 |
| NCBI Accession: | P46098.1 |
| UniProt Secondary Accession: | P46098,O60854, Q7KZM7, Q99918, Q9BSZ9, B4DSY6, G5E986 |
| UniProt Related Accession: | P46098 |
| Molecular Weight: | 478 |
| NCBI Full Name: | 5-hydroxytryptamine receptor 3A |
| NCBI Synonym Full Names: | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
| NCBI Official Symbol: | HTR3A |
| NCBI Official Synonym Symbols: | HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R |
| NCBI Protein Information: | 5-hydroxytryptamine receptor 3A; 5-HT3-A; serotonin receptor 3A; 5HT3 serotonin receptor; serotonin-gated ion channel receptor |
| UniProt Protein Name: | 5-hydroxytryptamine receptor 3A |
| UniProt Synonym Protein Names: | 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor |
| Protein Family: | 5-hydroxytryptamine receptor |
| UniProt Gene Name: | HTR3A |
| UniProt Entry Name: | 5HT3A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HTR3A antibody (CAB5647) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using HTR3A antibody (CAB5647) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using HTR3A antibody (CAB5647) at dilution of 1:100 (40x lens). |
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