Anti-HSCB Antibody (CAB15961)
- SKU:
- CAB15961
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-HSCB Antibody |
| 抗体コード: | CAB15961 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human HSCB (NP_741999.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-549, U-87MG, LO2, SGC-7901 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-235 of human HSCB (NP_741999.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AASQ AGSN YPRC WNCG GPWG PGRE DRFF CPQC RALQ APDP TRDY FSLM DCNR SFRV DTAK LQHR YQQL QRLV HPDF FSQR SQTE KDFS EKHS TLVN DAYK TLLA PLSR GLYL LKLH GIEI PERT DYEM DRQF LIEI MEIN EKLA EAES EAAM KEIE SIVK AKQK EFTD NVSS AFEQ DDFE EAKE ILTK MRYF SNIE EKIK LKKI PL |
| 遺伝子ID: | 150274 |
| Uniprot: | Q8IWL3 |
| セルラーロケーション: | Cytoplasm, Mitochondrion |
| 計算された分子量: | 27kDa |
| 観察された分子量: | 27kDa |
| 同義語: | HSCB, DNAJC20, HSC20, JAC1 |
| バックグラウンド: | This gene encodes a DnaJ-type co-chaperone and member of the heat shock cognate B (HscB) family of proteins. The encoded protein plays a role in the synthesis of iron-sulfur clusters, protein cofactors that are involved in the redox reactions of mitochondrial electron transport and other processes. Cells in which this gene is knocked down exhibit reduced activity of iron-sulfur cluster-dependent enzymes including succinate dehydrogenase and aconitase. The encoded protein may stimulate the ATPase activity of the mitochondrial stress-70 protein. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | HSCB: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. Belongs to the HscB family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Chaperone Chromosomal Location of Human Ortholog: 22q12.1 Cellular Component: centrosome; mitochondrion; cytoplasm; plasma membrane Molecular Function:protein binding; chaperone binding; metal ion binding Biological Process: protein folding; iron-sulfur cluster assembly; protein oligomerization |
| UniProt Code: | Q8IWL3 |
| NCBI GenInfo Identifier: | 50301234 |
| NCBI Gene ID: | 150274 |
| NCBI Accession: | NP_741999.3 |
| UniProt Secondary Accession: | Q8IWL3,Q9BWS7, |
| UniProt Related Accession: | Q8IWL3 |
| Molecular Weight: | 27,422 Da |
| NCBI Full Name: | iron-sulfur cluster co-chaperone protein HscB, mitochondrial |
| NCBI Synonym Full Names: | HscB mitochondrial iron-sulfur cluster co-chaperone |
| NCBI Official Symbol: | HSCB |
| NCBI Official Synonym Symbols: | JAC1; HSC20; DNAJC20; dJ366L4.2 |
| NCBI Protein Information: | iron-sulfur cluster co-chaperone protein HscB, mitochondrial; DnaJ (Hsp40) homolog, subfamily C, member 20; HscB iron-sulfur cluster co-chaperone homolog; J-type co-chaperone HSC20; dnaJ homolog subfamily C member 20 |
| UniProt Protein Name: | Iron-sulfur cluster co-chaperone protein HscB, mitochondrial |
| UniProt Synonym Protein Names: | DnaJ homolog subfamily C member 20; Hsc20 |
| Protein Family: | Co-chaperone protein |
| UniProt Gene Name: | HSCB |
| UniProt Entry Name: | HSC20_HUMAN |
 | Western blot analysis of extracts of various cell lines, using HSCB antibody (CAB15961) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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