Anti-GluA4 Antibody (CAB4593)
- SKU:
- CAB4593
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-GluA4 Antibody |
| 抗体コード: | CAB4593 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human GluA4 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Rat brain |
| 免疫原: | A synthesized peptide derived from human GluA4 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2893 |
| Uniprot: | P48058 |
| セルラーロケーション: | |
| 計算された分子量: | 101kDa |
| 観察された分子量: | 101KDa |
| 同義語: | GLUR4, GLUR4C, GLURD, GluA4 |
| バックグラウンド: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | GluR4: an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q22 Cellular Component: cell junction; cell soma; dendrite; plasma membrane; postsynaptic membrane; terminal button Molecular Function:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ionotropic glutamate receptor activity Biological Process: glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; synaptic transmission; transport |
| NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48058 |
| NCBI GenInfo Identifier: | 218512059 |
| NCBI Gene ID: | 2893 |
| NCBI Accession: | P48058.2 |
| UniProt Secondary Accession: | P48058,Q86XE8, |
| UniProt Related Accession: | P48058 |
| Molecular Weight: | 49,146 Da |
| NCBI Full Name: | Glutamate receptor 4 |
| NCBI Synonym Full Names: | glutamate ionotropic receptor AMPA type subunit 4 |
| NCBI Official Symbol: | GRIA4 |
| NCBI Official Synonym Symbols: | GLUR4; GLURD; GluA4; GLUR4C |
| NCBI Protein Information: | glutamate receptor 4 |
| UniProt Protein Name: | Glutamate receptor 4 |
| UniProt Synonym Protein Names: | AMPA-selective glutamate receptor 4; GluR-D; Glutamate receptor ionotropic, AMPA 4; GluA4 |
| Protein Family: | Glutamate receptor |
| UniProt Gene Name: | GRIA4 |
| UniProt Entry Name: | GRIA4_HUMAN |
 | Western blot - GluA4 Rabbit mAb (CAB4593) |
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