Anti-GLRB Antibody (CAB10505)
- SKU:
- CAB10505
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-GLRB Antibody |
| 抗体コード: | CAB10505 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-265 of human GLRB (NP_000815.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, NCI-H460, HT-1080, THP-1, Mouse brain, Mouse liver, Mouse eye, Rat brain, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-265 of human GLRB (NP_000815.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KEKS SKKG KGKK KQYL CPSQ QSAE DLAR VPAN STSN ILNR LLVS YDPR IRPN FKGI PVDV VVNI FINS FGSI QETT MDYR VNIF LRQK WNDP RLKL PSDF RGSD ALTV DPTM YKCL WKPD LFFA NEKS ANFH DVTQ ENIL LFIF RDGD VLVS MRLS ITLS CPLD LTLF PMDT QRCK MQLE SFGY TTDD LRFI WQSG DPVQ LEKI ALPQ FDIK KEDI EYGN CTKY YKGT GYYT CVEV IFTL RRQ |
| 遺伝子ID: | 2743 |
| Uniprot: | P48167 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 34kDa/56kDa |
| 観察された分子量: | 58kDa |
| 同義語: | GLRB, HKPX2 |
| バックグラウンド: | This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | GLRB: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRB are the cause of hyperekplexia type 2 (HKPX2). HKPX2 is a neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile2 stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub- subfamily. |
| UniProt Protein Details: | Protein type:Transporter, ion channel; Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Transporter Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:extracellular-glycine-gated chloride channel activity; extracellular-glycine-gated ion channel activity; glycine binding; protein binding Biological Process: ion transport; nervous system development; neuropeptide signaling pathway; response to amino acid stimulus; startle response; synaptic transmission; synaptic transmission, glycinergic Disease: Hyperekplexia 2 |
| NCBI Summary: | This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P48167 |
| NCBI GenInfo Identifier: | 1346173 |
| NCBI Gene ID: | 2743 |
| NCBI Accession: | P48167.1 |
| UniProt Secondary Accession: | P48167,A8K3K2, D3DP23, F5GWE1, |
| UniProt Related Accession: | P48167 |
| Molecular Weight: | 34,944 Da |
| NCBI Full Name: | Glycine receptor subunit beta |
| NCBI Synonym Full Names: | glycine receptor beta |
| NCBI Official Symbol: | GLRB |
| NCBI Official Synonym Symbols: | HKPX2 |
| NCBI Protein Information: | glycine receptor subunit beta |
| UniProt Protein Name: | Glycine receptor subunit beta |
| UniProt Synonym Protein Names: | Glycine receptor 58 kDa subunit |
| Protein Family: | Glycine receptor |
| UniProt Gene Name: | GLRB |
| UniProt Entry Name: | GLRB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using GLRB antibody (CAB10505) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose