Anti-GABRQ Antibody (CAB13226)
- SKU:
- CAB13226
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-GABRQ Antibody |
| 抗体コード: | CAB13226 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human GABRQ (NP_061028.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human GABRQ (NP_061028.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NYLF YSRG PRRQ PRRH RRPR RVIA RYRY QQVV VGNV QDGL INVE DGVS SLPI TPAQ APLA SPES LGSL TSTS EQAQ LATS ESLS PLTS LSGQ APLA TGES LSDL PSTS EQAR HSYG VRFN GFQA DDSI IPTE IRNR VEAH GHGV THDH EDSN ESLS SDER HGHG PSGK PMLH HGEK GVQE AGWD LDDN NDKS DCLA IKEQ FKCD TNST WGLN DDEL MAHG QEKD SSSE SEDS CPPS PGCS FTEG FSFD LFN |
| 遺伝子ID: | 55879 |
| Uniprot: | Q9UN88 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 72kDa |
| 観察された分子量: | 72kDa |
| 同義語: | GABRQ, THETA |
| バックグラウンド: | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). |
| UniProt Protein Function: | GABRQ: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRQ sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xq28 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:GABA-A receptor activity; neurotransmitter transporter activity; transmembrane receptor activity Biological Process: signal transduction |
| NCBI Summary: | The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes the theta subunit of the GABA A receptor. The gene is mapped to chromosome Xq28 in a cluster of genes including those that encode the alpha 3 and epsilon subunits of the GABA A receptor. This gene location is also the candidate region of two different neurologic diseases: early-onset parkinsonism (Waisman syndrome) and X-linked mental retardation (MRX3). [provided by RefSeq, Nov 2009] |
| UniProt Code: | Q9UN88 |
| NCBI GenInfo Identifier: | 13959382 |
| NCBI Gene ID: | 55879 |
| NCBI Accession: | Q9UN88.2 |
| UniProt Secondary Accession: | Q9UN88,Q32MB4, Q9NZK8, A6NFN1, |
| UniProt Related Accession: | Q9UN88 |
| Molecular Weight: | 72,022 Da |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit theta |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor theta subunit |
| NCBI Official Symbol: | GABRQ |
| NCBI Official Synonym Symbols: | THETA |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit theta |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit theta |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit theta |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRQ |
| UniProt Entry Name: | GBRT_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using GABRQ antibody (CAB13226) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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