Anti-GABRB3 Antibody (CAB10015)
- SKU:
- CAB10015
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-GABRB3 Antibody |
| 抗体コード: | CAB10015 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-460 of human GABRB3 (NP_000805.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human |
| ポジティブサンプル: | SH-SY5Y, A-549, BT-474 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 330-460 of human GABRB3 (NP_000805.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IFFG RGPQ RQKK LAEK TAKA KNDR SKSE SNRV DAHG NILL TSLE VHNE MNEV SGGI GDTR NSAI SFDN SGIQ YRKQ SMPR EGHG RFLG DRSL PHKK THLR RRSS QLKI KIPD LTDV NAID RWSR IVFP FTF |
| 遺伝子ID: | 2562 |
| Uniprot: | P28472 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 45kDa/46kDa/54kDa |
| 観察された分子量: | 65kDa |
| 同義語: | GABRB3, ECA5, EIEE43 |
| バックグラウンド: | This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
| UniProt Protein Function: | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. |
| NCBI Summary: | This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P28472 |
| NCBI GenInfo Identifier: | 4503867 |
| NCBI Gene ID: | 2562 |
| NCBI Accession: | NP_000805.1 |
| UniProt Secondary Accession: | P28472,Q14352, Q96FM5, B7Z2W1, B7Z825, F5H3D2, H7BYV8 |
| UniProt Related Accession: | P28472 |
| Molecular Weight: | 54,379 Da |
| NCBI Full Name: | gamma-aminobutyric acid receptor subunit beta-3 isoform 1 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor beta3 subunit |
| NCBI Official Symbol: | GABRB3 |
| NCBI Official Synonym Symbols: | ECA5; EIEE43 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit beta-3 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit beta-3 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit beta-3 |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRB3 |
 | Western blot analysis of extracts of various cell lines, using GABRB3 antibody (CAB10015) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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