Anti-GABRA6 Antibody (CAB12750)
- SKU:
- CAB12750
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-GABRA6 Antibody |
| 抗体コード: | CAB12750 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 344-453 of human GABRA6 (NP_000802.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, HT-1080, Mouse brain, Mouse liver, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 344-453 of human GABRA6 (NP_000802.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PPTV TISK ATEP LEAE IVLH PDSK YHLK KRIT SLSL PIVS SSEA NKVL TRAP ILQS TPVT PPPL SPAF GGTS KIDQ YSRI LFPV AFAG FNLV YWVV YLSK DTME VSSS VE |
| 遺伝子ID: | 2559 |
| Uniprot: | Q16445 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 51kDa |
| 観察された分子量: | 51kDa |
| 同義語: | GABRA6 |
| バックグラウンド: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. |
| UniProt Protein Function: | GABRA6: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily. |
| UniProt Protein Details: | Protein type:Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Chromosomal Location of Human Ortholog: 5q34 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:benzodiazepine receptor activity; GABA-A receptor activity Biological Process: signal transduction; transport |
| NCBI Summary: | GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16445 |
| NCBI GenInfo Identifier: | 126302548 |
| NCBI Gene ID: | 2559 |
| NCBI Accession: | Q16445.2 |
| UniProt Secondary Accession: | Q16445,Q4VAV2, A8K096, |
| UniProt Related Accession: | Q16445 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | Gamma-aminobutyric acid receptor subunit alpha-6 |
| NCBI Synonym Full Names: | gamma-aminobutyric acid type A receptor alpha6 subunit |
| NCBI Official Symbol: | GABRA6 |
| NCBI Protein Information: | gamma-aminobutyric acid receptor subunit alpha-6 |
| UniProt Protein Name: | Gamma-aminobutyric acid receptor subunit alpha-6 |
| UniProt Synonym Protein Names: | GABA(A) receptor subunit alpha-6 |
| Protein Family: | Gamma-aminobutyric acid receptor |
| UniProt Gene Name: | GABRA6 |
 | Western blot analysis of extracts of various cell lines, using GABRA6 antibody (CAB12750) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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