Anti-FLVCR2 Antibody (CAB7815)
- SKU:
- CAB7815
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-FLVCR2 Antibody |
| 抗体コード: | CAB7815 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FLVCR2 (NP_060261.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7, A-549, Mouse brain, Mouse lung, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FLVCR2 (NP_060261.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MVNE GPNQ EESD DTPV PESA LQAD PSVS VHPS VSVH PSVS INPS VSVH PSSS AHPS ALAQ PSGL AHPS SSGP EDLS VIKV SRRR WAVV LVFS CYSM CNSF |
| 遺伝子ID: | 55640 |
| Uniprot: | Q9UPI3 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 35kDa/57kDa |
| 観察された分子量: | 57kDa |
| 同義語: | FLVCR2, C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH |
| バックグラウンド: | This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | FLVCR2: Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism. Defects in FLVCR2 are the cause of proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH). It is a rare prenatally lethal disorder characterized by hydranencephaly, a distinctive glomerular vasculopathy in the central nervous system and retina, and diffuse ischemic lesions of the brain stem, basal ganglia, and spinal cord with calcifications. Hydranencephaly is a condition where the greater portions of the cerebral hemispheres and corpus striatum are replaced by cerebrospinal fluid and glial tissue. Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 14q24.3 Molecular Function:heme binding; heme transporter activity Disease: Proliferative Vasculopathy And Hydranencephaly-hydrocephaly Syndrome |
| NCBI Summary: | This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010] |
| UniProt Code: | Q9UPI3 |
| NCBI GenInfo Identifier: | 46396034 |
| NCBI Gene ID: | 55640 |
| NCBI Accession: | Q9UPI3.1 |
| UniProt Secondary Accession: | Q9UPI3,Q53ZT9, Q96JY3, Q9NX90, B7Z485, |
| UniProt Related Accession: | Q9UPI3 |
| Molecular Weight: | 35,262 Da |
| NCBI Full Name: | Feline leukemia virus subgroup C receptor-related protein 2 |
| NCBI Synonym Full Names: | feline leukemia virus subgroup C cellular receptor family member 2 |
| NCBI Official Symbol: | FLVCR2 |
| NCBI Official Synonym Symbols: | CCT; EPV; PVHH; MFSD7C; C14orf58; FLVCRL14q |
| NCBI Protein Information: | feline leukemia virus subgroup C receptor-related protein 2 |
| UniProt Protein Name: | Feline leukemia virus subgroup C receptor-related protein 2 |
| UniProt Synonym Protein Names: | Calcium-chelate transporter; CCT |
| Protein Family: | Feline leukemia virus subgroup C receptor-related protein |
| UniProt Gene Name: | FLVCR2 |
| UniProt Entry Name: | FLVC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FLVCR2 antibody (CAB7815) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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