Anti-FKBP5 Antibody (CAB3863)
- SKU:
- CAB3863
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-FKBP5 Antibody |
| 抗体コード: | CAB3863 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 308-457 of human FKBP5 (NP_001139247.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:200 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, HT-1080, SH-SY5Y, Jurkat, Mouse liver, Mouse kidney, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 308-457 of human FKBP5 (NP_001139247.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ESKA SESF LLAA FLNL AMCY LKLR EYTK AVEC CDKA LGLD SANE KGLY RRGE AQLL MNEF ESAK GDFE KVLE VNPQ NKAA RLQI SMCQ KKAK EHNE RDRR IYAN MFKK FAEQ DAKE EANK AMGK KTSE GVTN EKGT DSQA MEEE KPEG HV |
| 遺伝子ID: | 2289 |
| Uniprot: | Q13451 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 30kDa/51kDa |
| 観察された分子量: | 51kDa |
| 同義語: | FKBP5, AIG6, FKBP51, FKBP54, P54, PPIase, Ptg-10 |
| バックグラウンド: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin. |
| UniProt Protein Details: | Protein type:EC 5.2.1.8; Isomerase; Chaperone Chromosomal Location of Human Ortholog: 6p21.31 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane Molecular Function:protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; heat shock protein binding Biological Process: protein peptidyl-prolyl isomerization; protein folding Disease: Major Depressive Disorder |
| NCBI Summary: | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] |
| UniProt Code: | Q13451 |
| NCBI GenInfo Identifier: | 2851536 |
| NCBI Gene ID: | 2289 |
| NCBI Accession: | Q13451.2 |
| UniProt Related Accession: | Q13451 |
| Molecular Weight: | 51kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase FKBP5 |
| NCBI Synonym Full Names: | FKBP prolyl isomerase 5 |
| NCBI Official Symbol: | FKBP5 |
| NCBI Official Synonym Symbols: | P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase FKBP5 |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase FKBP5 |
| UniProt Synonym Protein Names: | 51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase |
| Protein Family: | FK506-binding protein |
| UniProt Gene Name: | FKBP5 |
| UniProt Entry Name: | FKBP5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FKBP5 antibody (CAB3863) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded human colon using FKBP5 antibody (CAB3863) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using FKBP5 antibody (CAB3863) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human uterus using FKBP5 antibody (CAB3863) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using FKBP5 antibody (CAB3863) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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