Anti-DYNLRB1 Antibody (CAB15197)
- SKU:
- CAB15197
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-DYNLRB1 Antibody |
| 抗体コード: | CAB15197 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-63 of human DYNLRB1 (NP_001268656.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, Mouse brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-63 of human DYNLRB1 (NP_001268656.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDNP TTTQ YASL MHSF ILKA RSTV RDID PQND LTFL RIRS KKNE IMVA PDKD YFLI VIQN PTE |
| 遺伝子ID: | 83658 |
| Uniprot: | Q9NP97 |
| セルラーロケーション: | Cytoplasm, cytoskeleton |
| 計算された分子量: | 5kDa/10kDa |
| 観察された分子量: | 20kDa |
| 同義語: | DYNLRB1, BITH, BLP, DNCL2A, DNLC2A, ROBLD1 |
| バックグラウンド: | This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. |
| UniProt Protein Function: | DYNLRB1: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Belongs to the GAMAD family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q11.22 Cellular Component: centrosome; cilium; cytoplasm; cytoplasmic dynein complex; membrane Molecular Function:dynein intermediate chain binding; protein binding Biological Process: microtubule-based movement; visual behavior |
| NCBI Summary: | This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9NP97 |
| NCBI GenInfo Identifier: | 528524492 |
| NCBI Gene ID: | 83658 |
| NCBI Accession: | NP_001268656.1 |
| UniProt Secondary Accession: | Q9NP97,Q5TC72, Q96IV3, Q9NQM2, B1AKR5, |
| UniProt Related Accession: | Q9NP97 |
| Molecular Weight: | 26.71kD |
| NCBI Full Name: | dynein light chain roadblock-type 1 isoform b |
| NCBI Synonym Full Names: | dynein light chain roadblock-type 1 |
| NCBI Official Symbol: | DYNLRB1 |
| NCBI Official Synonym Symbols: | BLP; BITH; DNCL2A; DNLC2A; ROBLD1 |
| NCBI Protein Information: | dynein light chain roadblock-type 1 |
| UniProt Protein Name: | Dynein light chain roadblock-type 1 |
| UniProt Synonym Protein Names: | Bithoraxoid-like protein; BLP; Dynein light chain 2A, cytoplasmic; Dynein-associated protein Km23; Roadblock domain-containing protein 1 |
| Protein Family: | Dynein |
| UniProt Gene Name: | DYNLRB1 |
 | Western blot analysis of extracts of various cell lines, using DYNLRB1 antibody (CAB15197) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded Human thyroid cancer using DYNLRB1 Rabbit pAb (CAB15197) at dilution of 1:100 (40x lens). |
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