Anti-DGKZ Antibody (CAB16457)
- SKU:
- CAB16457
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-DGKZ Antibody |
| 抗体コード: | CAB16457 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 808-1117 of human DGKZ (NP_001099010.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2, HeLa, 293T, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 808-1117 of human DGKZ (NP_001099010.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ATMV QKAK RRSA APLH SDQQ PVPE QLRI QVSR VSMH DYEA LHYD KEQL KEAS VPLG TVVV PGDS DLEL CRAH IERL QQEP DGAG AKSP TCQK LSPK WCFL DATT ASRF YRID RAQE HLNY VTEI AQDE IYIL DPEL LGAS ARPD LPTP TSPL PTSP CSPT PRSL QGDA APPQ GEEL IEAA KRND FCKL QELH RAGG DLMH RDEQ SRTL LHHA VSTG SKDV VRYL LDHA PPEI LDAV EENG ETCL HQAA ALGQ RTIC HYIV EAGA SLMK TDQQ GDTP RQRA EKAQ DTEL AAYL ENRQ HYQM IQRE DQET AV |
| 遺伝子ID: | 8525 |
| Uniprot: | Q13574 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Nucleus |
| 計算された分子量: | 101kDa/103kDa/104kDa/106kDa/124kDa |
| 観察された分子量: | 120kDa |
| 同義語: | DGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta |
| バックグラウンド: | The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. |
| UniProt Protein Function: | DGKZ: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity. Belongs to the eukaryotic diacylglycerol kinase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Kinase, lipid; EC 2.7.1.107; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: lamellipodium; nucleoplasm; nucleus; plasma membrane Molecular Function:diacylglycerol kinase activity; protein binding Biological Process: platelet activation |
| NCBI Summary: | The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q13574 |
| NCBI GenInfo Identifier: | 215274170 |
| NCBI Gene ID: | 8525 |
| NCBI Accession: | Q13574.3 |
| UniProt Secondary Accession: | Q13574,O00542, Q6ZVG7, Q8IVW9, B7Z2M9, B7Z6M3, E9PPW4 F6UCU9, G3V0F6, J3KNJ6, |
| UniProt Related Accession: | Q13574 |
| Molecular Weight: | 104,296 Da |
| NCBI Full Name: | Diacylglycerol kinase zeta |
| NCBI Synonym Full Names: | diacylglycerol kinase zeta |
| NCBI Official Symbol: | DGKZ |
| NCBI Official Synonym Symbols: | DAGK5; DAGK6; DGK-ZETA; hDGKzeta |
| NCBI Protein Information: | diacylglycerol kinase zeta |
| UniProt Protein Name: | Diacylglycerol kinase zeta |
| UniProt Synonym Protein Names: | Diglyceride kinase zeta; DGK-zeta |
| Protein Family: | Diacylglycerol kinase |
| UniProt Gene Name: | DGKZ |
| UniProt Entry Name: | DGKZ_HUMAN |
 | Western blot analysis of extracts of various cell lines, using DGKZ antibody (CAB16457) at 1:300 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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