Anti-CNGA4 Antibody (CAB14720)
- SKU:
- CAB14720
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CNGA4 Antibody |
| 抗体コード: | CAB14720 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | NCI-H460, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ISII NIKG NMSG NRRT ANIK SLGY SDLF CLSK EDLR EVLS EYPQ AQTI MEEK GREI LLKM NKLD VNAE AAEI ALQE ATES RLRG LDQQ LDDL QTKF ARLL AELE SSAL KIAY RIER LEWQ TREW PMPE DLAE ADDE GEPE EGTS KDEE GRAS QEGP PGPE |
| 遺伝子ID: | 1262 |
| Uniprot: | Q8IV77 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 47kDa/65kDa |
| 観察された分子量: | 66kDa |
| 同義語: | CNGA4, CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb |
| バックグラウンド: |
| UniProt Protein Function: | CNGA4: Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA4 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: Golgi membrane; integral to plasma membrane Molecular Function:cGMP binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; voltage-gated potassium channel activity Biological Process: regulation of membrane potential |
| NCBI Summary: | CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001 [PubMed 11739959]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8IV77 |
| NCBI GenInfo Identifier: | 311033466 |
| NCBI Gene ID: | 1262 |
| NCBI Accession: | Q8IV77.3 |
| UniProt Related Accession: | Q8IV77 |
| Molecular Weight: | 47,743 Da |
| NCBI Full Name: | Cyclic nucleotide-gated cation channel alpha-4 |
| NCBI Synonym Full Names: | cyclic nucleotide gated channel alpha 4 |
| NCBI Official Symbol: | CNGA4 |
| NCBI Official Synonym Symbols: | CNG4; CNG5; CNCA2; CNG-4; CNGB2; OCNC2; OCNCb; OCNCBETA |
| NCBI Protein Information: | cyclic nucleotide-gated cation channel alpha-4 |
| UniProt Protein Name: | Cyclic nucleotide-gated cation channel alpha-4 |
| UniProt Synonym Protein Names: | Cyclic nucleotide-gated channel alpha-4; CNG channel alpha-4; CNG-4; CNG4 |
| Protein Family: | Cyclic nucleotide-gated cation channel |
| UniProt Gene Name: | CNGA4 |
| UniProt Entry Name: | CNGA4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CNGA4 antibody (CAB14720) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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