Anti-CLPB Antibody (CAB9130)
- SKU:
- CAB9130
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CLPB Antibody |
| 抗体コード: | CAB9130 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-707 of human CLPB (NP_110440.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, MCF7, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-707 of human CLPB (NP_110440.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KAHP DVLT IMLQ LFDE GRLT DGKG KTID CKDA IFIM TSNV ASDE IAQH ALQL RQEA LEMS RNRI AENL GDVQ ISDK ITIS KNFK ENVI RPIL KAHF RRDE FLGR INEI VYFL PFCH SELI QLVN KELN FWAK RAKQ RHNI TLLW DREV ADVL VDGY NVHY GARS IKHE VERR VVNQ LAAA YEQD LLPG GCTL RITV EDSD KQLL KSPE LPSP QAEK RLPK LRLE IIDK DSKT RRLD IRAP LHPE KVCN TI |
| 遺伝子ID: | 81570 |
| Uniprot: | Q9H078 |
| セルラーロケーション: | Mitochondrion |
| 計算された分子量: | 57kDa/72kDa/74kDa/75kDa/78kDa |
| 観察された分子量: | 79kDa |
| 同義語: | CLPB, ANKCLB, HSP78, MEGCANN, MGCA7, SKD3 |
| バックグラウンド: | This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CLPB: May function as a regulatory ATPase and be related to secretion/protein trafficking process. Belongs to the clpA/clpB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 11q13.4 Molecular Function:protein binding Disease: 3-methylglutaconic Aciduria With Cataracts, Neurologic Involvement, And Neutropenia |
| NCBI Summary: | This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015] |
| UniProt Code: | Q9H078 |
| NCBI GenInfo Identifier: | 25009267 |
| NCBI Gene ID: | 81570 |
| NCBI Accession: | Q9H078.1 |
| UniProt Secondary Accession: | Q9H078,Q8ND11, Q9H8Y0, B4DXJ7, B4DXP7, B4DXW4, E7EWN6 F8W7P6, |
| UniProt Related Accession: | Q9H078 |
| Molecular Weight: | 57,664 Da |
| NCBI Full Name: | Caseinolytic peptidase B protein homolog |
| NCBI Synonym Full Names: | ClpB homolog, mitochondrial AAA ATPase chaperonin |
| NCBI Official Symbol: | CLPB |
| NCBI Official Synonym Symbols: | SKD3; HSP78; MGCA7; ANKCLB; MEGCANN |
| NCBI Protein Information: | caseinolytic peptidase B protein homolog |
| UniProt Protein Name: | Caseinolytic peptidase B protein homolog |
| UniProt Synonym Protein Names: | Suppressor of potassium transport defect 3 |
| Protein Family: | Chaperone protein |
| UniProt Gene Name: | CLPB |
| UniProt Entry Name: | CLPB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLPB antibody (CAB9130) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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