Anti-CLCNKA Antibody (CAB3792)
- SKU:
- CAB3792
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CLCNKA Antibody |
| 抗体コード: | CAB3792 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-644 of human CLCNKA (NP_001244068.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2, HT-29, A-549 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-644 of human CLCNKA (NP_001244068.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QSCQ PSFY DGTI IVKK LPYL PRIL GRNI GSHH VRVE HFMN HSIT TLAK DTPL EEVV KVVT STDV TEYP LVES TESQ ILVG IVQR AQLV QALQ AEPP SRAP GHQQ CLQD ILAR GCPT EPVT LTLF SETT LHQA QNLF KLLN LQSL FVTS RGRA VGCV SWVE MKKA ISNL TNPP APK |
| 遺伝子ID: | 1187 |
| Uniprot: | P51800 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 70kDa/75kDa |
| 観察された分子量: | 75kDa |
| 同義語: | CLCNKA, CLCK1, ClC-K1, hClC-Ka |
| バックグラウンド: | This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CLCNKA: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKA are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily. |
| UniProt Protein Details: | Protein type:Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 1p36 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:metal ion binding; voltage-gated chloride channel activity Biological Process: transport; excretion; transmembrane transport Disease: Bartter Syndrome, Type 4b |
| NCBI Summary: | This gene is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51800 |
| NCBI GenInfo Identifier: | 1705857 |
| NCBI Gene ID: | 1187 |
| NCBI Accession: | P51800.1 |
| UniProt Secondary Accession: | P51800,Q5T5P8, Q5T5Q4, Q7Z6D1, Q86VT1, B4DPD3, E7EPH6 |
| UniProt Related Accession: | P51800 |
| Molecular Weight: | |
| NCBI Full Name: | Chloride channel protein ClC-Ka |
| NCBI Synonym Full Names: | chloride channel, voltage-sensitive Ka |
| NCBI Official Symbol: | CLCNKA |
| NCBI Official Synonym Symbols: | CLCK1; ClC-K1; hClC-Ka |
| NCBI Protein Information: | chloride channel protein ClC-Ka; chloride channel Ka; chloride channel, kidney, A |
| UniProt Protein Name: | Chloride channel protein ClC-Ka |
| UniProt Synonym Protein Names: | ClC-K1 |
| Protein Family: | Chloride channel protein |
| UniProt Gene Name: | CLCNKA |
| UniProt Entry Name: | CLCKA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLCNKA Antibody (CAB3792) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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