Anti-ASIC2 Antibody (CAB10496)
- SKU:
- CAB10496
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-ASIC2 Antibody |
| 抗体コード: | CAB10496 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human ASIC2 (NP_001085.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, 293T, Mouse brain, Rat brain, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-400 of human ASIC2 (NP_001085.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NLQI PDPH LADP SVLE ALRQ KANF KHYK PKQF SMLE FLHR VGHD LKDM MLYC KFKG QECG HQDF TTVF TKYG KCYM FNSG EDGK PLLT TVKG GTGN GLEI MLDI QQDE YLPI WGET EETT FEAG VKVQ IHSQ SEPP FIQE LGFG VAPG FQTF VATQ EQRL TYLP PPWG ECRS SEMG LDFF PVYS ITAC RIDC ETRY IVEN CNCR MVHM PGDA PFCT PEQH KECA EPAL GLLA EKDS NYCL CRTP CNLT RYNK ELSM VKIP SKTS AKYL EKKF NKSE KYIS E |
| 遺伝子ID: | 40 |
| Uniprot: | Q16515 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 57kDa/62kDa |
| 観察された分子量: | 58kDa |
| 同義語: | ASIC2, ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1 |
| バックグラウンド: | This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. |
| UniProt Protein Function: | ASIC2: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, cation; Apoptosis; Transporter, ion channel; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 17q12 Cellular Component: plasma membrane Molecular Function:amiloride-sensitive sodium channel activity; protein binding Biological Process: central nervous system development; monovalent inorganic cation transport; peripheral nervous system development; regulation of blood coagulation; regulation of gene expression; sensory perception of sour taste; synaptic transmission |
| NCBI Summary: | This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q16515 |
| NCBI GenInfo Identifier: | 2500840 |
| NCBI Gene ID: | 40 |
| NCBI Accession: | Q16515.1 |
| UniProt Secondary Accession: | Q16515,Q13553, Q6DJU1, Q8N3E2, E9PBX2, |
| UniProt Related Accession: | Q16515 |
| Molecular Weight: | 62,887 Da |
| NCBI Full Name: | Acid-sensing ion channel 2 |
| NCBI Synonym Full Names: | acid sensing ion channel subunit 2 |
| NCBI Official Symbol: | ASIC2 |
| NCBI Official Synonym Symbols: | ACCN; BNC1; MDEG; ACCN1; BNaC1; ASIC2a; hBNaC1 |
| NCBI Protein Information: | acid-sensing ion channel 2 |
| UniProt Protein Name: | Acid-sensing ion channel 2 |
| UniProt Synonym Protein Names: | Amiloride-sensitive brain sodium channel; Amiloride-sensitive cation channel 1, neuronal; Amiloride-sensitive cation channel neuronal 1; Brain sodium channel 1; BNC1; BNaC1; Mammalian degenerin homolog |
| Protein Family: | Acid-sensing ion channel |
| UniProt Gene Name: | ASIC2 |
| UniProt Entry Name: | ASIC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ASIC2 antibody (CAB10496) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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