| バックグラウンド: | The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. |
| UniProt Protein Function: | ASB7: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 15q26.3 Molecular Function:protein binding |
| NCBI Summary: | The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H672 |
| NCBI GenInfo Identifier: | 38372887 |
| NCBI Gene ID: | 140460 |
| NCBI Accession: | Q9H672.2 |
| UniProt Secondary Accession: | Q9H672,Q6GSJ6, Q7Z4S3, A8K1E5, |
| UniProt Related Accession: | Q9H672 |
| Molecular Weight: | 30,713 Da |
| NCBI Full Name: | Ankyrin repeat and SOCS box protein 7 |
| NCBI Synonym Full Names: | ankyrin repeat and SOCS box containing 7 |
| NCBI Official Symbol: | ASB7 |
| NCBI Protein Information: | ankyrin repeat and SOCS box protein 7 |
| UniProt Protein Name: | Ankyrin repeat and SOCS box protein 7 |
| Protein Family: | Ankyrin repeat and SOCS box protein |
| UniProt Gene Name: | ASB7 |
| UniProt Entry Name: | ASB7_HUMAN |
