Anti-AQP1 Antibody (CAB15030)
- SKU:
- CAB15030
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| 抗体名: | Anti-AQP1 Antibody |
| 抗体コード: | CAB15030 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human AQP1 (NP_932766.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HeLa, Mouse brain, Mouse heart, Mouse kidney, Rat kidney |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human AQP1 (NP_932766.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AVIT HNFS NHWI FWVG PFIG GALA VLIY DFIL APRS SDLT DRVK VWTS GQVE EYDL DADD INSR VEMK PK |
| 遺伝子ID: | 358 |
| Uniprot: | P29972 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 16kDa/19kDa/23kDa/28kDa |
| 観察された分子量: | 28kDa |
| 同義語: | AQP1, AQP-CHIP, CHIP28, CO |
| バックグラウンド: | Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | AQP1: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Belongs to the MIP/aquaporin (TC 1.A.8) family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, aquaporin family Chromosomal Location of Human Ortholog: 7p14 Cellular Component: nuclear membrane; apical part of cell; integral to plasma membrane; brush border membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; basal plasma membrane; plasma membrane; nerve terminal; nucleus; sarcolemma; brush border Molecular Function:protein binding; ephrin receptor binding; potassium channel activity; water transporter activity; intracellular cGMP activated cation channel activity; ammonium transmembrane transporter activity; glycerol transmembrane transporter activity; potassium ion transmembrane transporter activity; nitric oxide transporter activity; water channel activity; transmembrane transporter activity; glycerol channel activity Biological Process: cGMP biosynthetic process; glycerol transport; cerebrospinal fluid secretion; wound healing; cellular response to stress; water transport; carbon dioxide transport; negative regulation of caspase activity; sensory perception of pain; pancreatic juice secretion; positive regulation of saliva secretion; odontogenesis; positive regulation of fibroblast proliferation; nitric oxide transport; hyperosmotic salinity response; bicarbonate transport; multicellular organismal water homeostasis; cellular homeostasis; transmembrane transport; lipid digestion; potassium ion transport; lateral ventricle development; response to drug; cellular water homeostasis; secretory granule organization and biogenesis; glomerular filtration; ammonium transport; positive regulation of angiogenesis; renal water transport; camera-type eye morphogenesis; response to estrogen stimulus; adrenocorticotropin hormone secretion; establishment and/or maintenance of actin cytoskeleton polarity; renal water homeostasis; cell volume homeostasis; negative regulation of apoptosis Disease: Blood Group--colton |
| NCBI Summary: | Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P29972 |
| NCBI GenInfo Identifier: | 267412 |
| NCBI Gene ID: | 358 |
| NCBI Accession: | P29972.3 |
| UniProt Secondary Accession: | P29972,Q8TBI5, Q8TDC1, B5BU39, E7EM69, E9PC21, F5GY19 |
| UniProt Related Accession: | P29972 |
| Molecular Weight: | 16,677 Da |
| NCBI Full Name: | Aquaporin-1 |
| NCBI Synonym Full Names: | aquaporin 1 (Colton blood group) |
| NCBI Official Symbol: | AQP1 |
| NCBI Official Synonym Symbols: | CO; CHIP28; AQP-CHIP |
| NCBI Protein Information: | aquaporin-1; aquaporin-CHIP; urine water channel; channel-like integral membrane protein, 28-kDa; water channel protein for red blood cells and kidney proximal tubule; aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group) |
| UniProt Protein Name: | Aquaporin-1 |
| UniProt Synonym Protein Names: | Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule |
| UniProt Gene Name: | AQP1 |
| UniProt Entry Name: | AQP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AQP1 antibody (CAB15030) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |