Anti-AGRP Antibody (CAB8044)
- SKU:
- CAB8044
- Product type:
- Antibody
- Application:
- IHC
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | AGRP Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8044 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1). |
| 申し込み: | IHC |
| 推奨希釈: | IHC 1:50 - 1:200 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-132 of human AGRP (NP_001129.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AQMG LAPM EGIR RPDQ ALLP ELPG LGLR APLK KTTA EQAE EDLL QEAQ ALAE VLDL QDRE PRSS RRCV RLHE SCLG QQVP CCDP CATC YCRF FNAF CYCR KLGT AMNP CSRT |
| 遺伝子ID: | 181 |
| Uniprot: | O00253 |
| セルラーロケーション: | Golgi apparatus lumen, Secreted |
| 計算された分子量: | 14kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | AGRP, AGRT, ART, ASIP2 |
| バックグラウンド: | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. |
| UniProt Protein Function: | AGRP: Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. Genetic variations in AGRP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. |
| UniProt Protein Details: | Protein type:Secreted; Hormone; Secreted, signal peptide Chromosomal Location of Human Ortholog: 16q22 Cellular Component: extracellular space; cell soma; Golgi lumen Molecular Function:neuropeptide hormone activity; receptor binding Biological Process: maternal process involved in pregnancy; hormone-mediated signaling; eating behavior; neuropeptide signaling pathway; photoperiodism; feeding behavior; adult feeding behavior; response to insulin stimulus Disease: Obesity |
| NCBI Summary: | This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009] |
| UniProt Code: | O00253 |
| NCBI GenInfo Identifier: | 4501995 |
| NCBI Gene ID: | 181 |
| NCBI Accession: | NP_001129.1 |
| UniProt Secondary Accession: | O00253,O15459, Q2TBD9, |
| UniProt Related Accession: | O00253 |
| Molecular Weight: | |
| NCBI Full Name: | agouti-related protein |
| NCBI Synonym Full Names: | agouti related neuropeptide |
| NCBI Official Symbol: | AGRP |
| NCBI Official Synonym Symbols: | ART; AGRT; ASIP2 |
| NCBI Protein Information: | agouti-related protein; agouti related protein homolog |
| UniProt Protein Name: | Agouti-related protein |
| Protein Family: | Agouti-related protein |
| UniProt Gene Name: | AGRP |
| UniProt Entry Name: | AGRP_HUMAN |
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