Anti-ACMSD Antibody (CAB15953)
- SKU:
- CAB15953
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-ACMSD Antibody |
| 抗体コード: | CAB15953 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_612199.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse liver, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_612199.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKID IHSH ILPK EWPD LKKR FGYG GWVQ LQHH SKGE AKLL KDGK VFRV VREN CWDP EVRI REMD QKGV TVQA LSTV PVMF SYWA KPED TLNL CQLL NNDL ASTV VSYP RRFV GLGT LPMQ APEL AVKE MERC VKEL GFPG VQIG THVN EWDL NAQE LFPV YAAA ERLK CSLF VHPW DMQM DGRM AKYW LPWL VGMP AETT IAIC SMIM GGVF EKFP KLKV CFAH GGGA FPFT VGRI SHGF SMRP DLCA QDNP MNPK KYLG SFYT DALV HDPL SLKL LTDV IGKD KVIL GTDY PFPL GELE PGKL IESM EEFD EETK NKLK AGNA LAFL GLER KQFE |
| 遺伝子ID: | 130013 |
| Uniprot: | Q8TDX5 |
| セルラーロケーション: | |
| 計算された分子量: | 31kDa/38kDa |
| 観察された分子量: | 38kDa |
| 同義語: | ACMSD |
| バックグラウンド: | The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. |
| UniProt Protein Function: | ACMSD: Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Belongs to the ACMSD family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 4.1.1.45; Amino Acid Metabolism - tryptophan; Lyase Chromosomal Location of Human Ortholog: 2q21.3 Cellular Component: cytosol Molecular Function:aminocarboxymuconate-semialdehyde decarboxylase activity; metal ion binding Biological Process: quinolinate metabolic process; tryptophan catabolic process |
| NCBI Summary: | The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004] |
| UniProt Code: | Q8TDX5 |
| NCBI GenInfo Identifier: | 37999723 |
| NCBI Gene ID: | 130013 |
| NCBI Accession: | Q8TDX5.1 |
| UniProt Secondary Accession: | Q8TDX5,Q3B7X3, Q53SR5, Q96KY2, |
| UniProt Related Accession: | Q8TDX5 |
| Molecular Weight: | 31,213 Da |
| NCBI Full Name: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
| NCBI Synonym Full Names: | aminocarboxymuconate semialdehyde decarboxylase |
| NCBI Official Symbol: | ACMSD |
| NCBI Protein Information: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase |
| UniProt Protein Name: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
| UniProt Synonym Protein Names: | Picolinate carboxylase |
| Protein Family: | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase |
| UniProt Gene Name: | ACMSD |
| UniProt Entry Name: | ACMSD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ACMSD antibody (CAB15953) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose