Anti-ACKR3 Antibody (CAB12712)
- SKU:
- CAB12712
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-ACKR3 Antibody |
| 抗体コード: | CAB12712 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACKR3 (NP_064707.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 4T1, Mouse brain, Mouse lung |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACKR3 (NP_064707.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IYIF IFVI GMIA NSVV VWVN IQAK TTGY DTHC YILN LAIA DLWV VLTI PVWV VSLV QHNQ WPMG ELTC KVTH LIFS INLF GSIF FLTC MSVD RYLS ITYF T |
| 遺伝子ID: | 57007 |
| Uniprot: | P25106 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Early endosome, Multi-pass membrane protein, Recycling endosome, perinuclear region |
| 計算された分子量: | 41kDa |
| 観察された分子量: | 44KDa |
| 同義語: | ACKR3, CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1 |
| バックグラウンド: | This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. |
| UniProt Protein Function: | CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cell surface; coated pit; endosome; intracellular membrane-bound organelle; plasma membrane Molecular Function:C-X-C chemokine binding; C-X-C chemokine receptor activity; protein binding; scavenger receptor activity Biological Process: receptor internalization |
| NCBI Summary: | This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25106 |
| NCBI GenInfo Identifier: | 115502380 |
| NCBI Gene ID: | 57007 |
| NCBI Accession: | P25106.3 |
| UniProt Secondary Accession: | P25106,Q53RV4, Q8NE10, Q92938, Q92986, A8K6J4, |
| UniProt Related Accession: | P25106 |
| Molecular Weight: | 41,493 Da |
| NCBI Full Name: | Atypical chemokine receptor 3 |
| NCBI Synonym Full Names: | atypical chemokine receptor 3 |
| NCBI Official Symbol: | ACKR3 |
| NCBI Official Synonym Symbols: | RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159 |
| NCBI Protein Information: | atypical chemokine receptor 3 |
| UniProt Protein Name: | Atypical chemokine receptor 3 |
| UniProt Synonym Protein Names: | C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1 |
| Protein Family: | Non-reducing polyketide synthase |
| UniProt Gene Name: | ACKR3 |
 | Western blot analysis of extracts of various cell lines, using ACKR3 Rabbit pAb (CAB12712) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of Mouse skin using ACKR3 Rabbit pAb (CAB12712) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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