Anti-ABCC5 Antibody (CAB11978)
- SKU:
- CAB11978
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-ABCC5 Antibody |
| 抗体コード: | CAB11978 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ABCC5 (NP_005679.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | HeLa |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ABCC5 (NP_005679.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKDI DIGK EYII PSPG YRSV RERT STSG THRD REDS KFRR TRPL ECQD ALET AARA EGLS LDAS MHSQ LRIL DEEH PKGK YHHG LSAL KPIR TTSK HQHP |
| 遺伝子ID: | 10057 |
| Uniprot: | O15440 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 23kDa/25kDa/155kDa/160kDa |
| 観察された分子量: | 161kDa |
| 同義語: | ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 |
| バックグラウンド: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ABCC5: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: integral to plasma membrane; membrane; plasma membrane Molecular Function:anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity Biological Process: hyaluronan biosynthetic process; transmembrane transport; transport |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
| UniProt Code: | O15440 |
| NCBI GenInfo Identifier: | 8928547 |
| NCBI Gene ID: | 10057 |
| NCBI Accession: | O15440.2 |
| UniProt Secondary Accession: | O15440,O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85 Q9UNP5, Q9UQC3, B9EIQ2, |
| UniProt Related Accession: | O15440 |
| Molecular Weight: | 161kDa |
| NCBI Full Name: | Multidrug resistance-associated protein 5 |
| NCBI Synonym Full Names: | ATP binding cassette subfamily C member 5 |
| NCBI Official Symbol: | ABCC5 |
| NCBI Official Synonym Symbols: | MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145 |
| NCBI Protein Information: | multidrug resistance-associated protein 5 |
| UniProt Protein Name: | Multidrug resistance-associated protein 5 |
| UniProt Synonym Protein Names: | ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11 |
| Protein Family: | ABC transporter C family |
| UniProt Gene Name: | ABCC5 |
 | Western blot analysis of extracts of HeLa cells, using ABCC5 antibody (CAB11978) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using ABCC5 antibody (CAB11978) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using ABCC5 antibody (CAB11978) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using ABCC5 antibody (CAB11978) at dilution of 1:100 (40x lens). |
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