| UniProt Protein Function: | TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Cell development/differentiation; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane Molecular Function:protein binding Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis |
| UniProt Code: | Q9NP84 |
| NCBI GenInfo Identifier: | 21263626 |
| NCBI Gene ID: | 51330 |
| NCBI Accession: | Q9NP84.1 |
| UniProt Secondary Accession: | Q9NP84,Q9HCS0, D3DUA6, |
| UniProt Related Accession: | Q9NP84 |
| Molecular Weight: | 10,191 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 12A |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 12A |
| NCBI Official Symbol: | TNFRSF12A |
| NCBI Official Synonym Symbols: | FN14; CD266; TWEAKR |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 12A |
| UniProt Synonym Protein Names: | Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266 |
| UniProt Gene Name: | TNFRSF12A |
| UniProt Entry Name: | TNR12_HUMAN |
