Anti-ZYX Antibody (CAB2135)
- SKU:
- CAB2135
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-ZYX Antibody |
抗体コード: | CAB2135 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ZYX (NP_001010972.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human ZYX (NP_001010972.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MAAP RPSP AISV SVSA PAFY APQK KFGP VVAP KPKV NPFR PGDS EPPP APGA QRAQ MGRV GEIP PPPP EDFP LPPP PLAG DGDD AEGA LGGA FPPP PPPI EESF PPAP LEEE IFPS PPPP PEEE GGPE APIP PPPQ PREK VSSI DLEI DSLS SLLD DMTK NDPF KARV SSGY VPPP VATP FSSK SSTK PAAG GTAP LPPW KSPS SSQP LPQV PAPA QSQT QFHV QPQP QPKP QVQL HVQS QTQP VSLA NTQP RGPP ASSP APAP KFSP VTPK FTPV ASKF SPGA PGGS GSQP NQKL GHPE |
遺伝子ID: | 7791 |
Uniprot: | Q15942 |
セルラーロケーション: | Cell junction, Cytoplasm, Nucleus, cytoskeleton, focal adhesion |
計算された分子量: | 45kDa/61kDa |
観察された分子量: | 78kDa |
同義語: | ZYX, ESP-2, HED-2, zyxin |
バックグラウンド: | Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. |
UniProt Protein Function: | Zyxin: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression. Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Belongs to the zyxin/ajuba family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion Chromosomal Location of Human Ortholog: 7q32 Cellular Component: focal adhesion; cell-cell adherens junction; integral to plasma membrane; cytoplasm; stress fiber; plasma membrane; nucleus Molecular Function:protein binding; zinc ion binding Biological Process: integrin-mediated signaling pathway; cell-cell signaling; viral reproduction; transforming growth factor beta receptor signaling pathway; cell-matrix adhesion; regulation of inflammatory response; stress fiber formation; signal transduction; cell adhesion |
NCBI Summary: | Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q15942 |
NCBI GenInfo Identifier: | 2497677 |
NCBI Gene ID: | 7791 |
NCBI Accession: | Q15942.1 |
UniProt Secondary Accession: | Q15942,Q6I9S4, A4D2G6, B4DQX7, |
UniProt Related Accession: | Q15942 |
Molecular Weight: | 572 |
NCBI Full Name: | Zyxin |
NCBI Synonym Full Names: | zyxin |
NCBI Official Symbol: | ZYX |
NCBI Official Synonym Symbols: | ESP-2; HED-2 |
NCBI Protein Information: | zyxin; zyxin-2 |
UniProt Protein Name: | Zyxin |
UniProt Synonym Protein Names: | Zyxin-2 |
Protein Family: | Zyxin |
UniProt Gene Name: | ZYX |
UniProt Entry Name: | ZYX_HUMAN |
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