Anti-ZP4 Antibody (CAB15180)
- SKU:
- CAB15180
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-ZP4 Antibody |
| 抗体コード: | CAB15180 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ZP4 (NP_067009.1). |
| 申し込み: | IHC |
| 推奨希釈: | IHC 1:50 - 1:200 |
| 反応性: | Rat |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ZP4 (NP_067009.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IPVQ KALD LPFP SHHQ RFSI FTFS FVNP TVEK QALR GPVH LHCS VSVC QPAE TPSC VVTC PDLS RRRN FDNS SQNT TASV SSKG PMIL LQAT KDPP EKLR V |
| 遺伝子ID: | 57829 |
| Uniprot: | Q12836 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein, extracellular matrix, extracellular space |
| 計算された分子量: | 59kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | ZP4, ZBP, ZP1, ZPB, Zp-4 |
| バックグラウンド: | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. |
| UniProt Protein Function: | ZP4: The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. Belongs to the ZP domain family. ZPB subfamily. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q43 Cellular Component: extracellular region Molecular Function:acrosin binding; signal transducer activity Biological Process: binding of sperm to zona pellucida; positive regulation of humoral immune response; positive regulation of protein kinase activity; positive regulation of T cell proliferation |
| NCBI Summary: | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12836 |
| NCBI GenInfo Identifier: | 46397080 |
| NCBI Gene ID: | 57829 |
| NCBI Accession: | Q12836.1 |
| UniProt Secondary Accession: | Q12836,B2RAE1, |
| UniProt Related Accession: | Q12836 |
| Molecular Weight: | 59,400 Da |
| NCBI Full Name: | Zona pellucida sperm-binding protein 4 |
| NCBI Synonym Full Names: | zona pellucida glycoprotein 4 |
| NCBI Official Symbol: | ZP4 |
| NCBI Official Synonym Symbols: | ZBP; ZP1; ZPB; Zp-4 |
| NCBI Protein Information: | zona pellucida sperm-binding protein 4 |
| UniProt Protein Name: | Zona pellucida sperm-binding protein 4 |
| UniProt Synonym Protein Names: | Zona pellucida glycoprotein 4; Zp-4 |
| Protein Family: | Zona pellucida sperm-binding protein |
| UniProt Gene Name: | ZP4 |
| UniProt Entry Name: | ZP4_HUMAN |
 | Immunohistochemistry of paraffin-embedded Rat ovary using ZP4 Rabbit pAb (CAB15180) at dilution of 1:100 (40x lens). |
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