Anti-ZBP1 Antibody (CAB13899)
- SKU:
- CAB13899
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-ZBP1 Antibody |
| 抗体コード: | CAB13899 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ZBP1 (NP_110403.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | mouse lung, rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ZBP1 (NP_110403.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAQA PADP GREG HLEQ RILQ VLTE AGSP VKLA QLVK ECQA PKRE LNQV LYRM KKEL KVSL TSPA TWCL GGTD PEGE GPAE LALS SPAE RPQQ HAAT IPET PGPQ FSQQ REED IYRF LKDN GPQR ALVI AQAL GMRT AKDV NRDL YRMK SRHL LDMD EQSK AWTI YRPE DSGR RAKS ASII YQHN PINM ICQN GPNS WISI |
| 遺伝子ID: | 81030 |
| Uniprot: | Q9H171 |
| セルラーロケーション: | |
| 計算された分子量: | 15kDa/27kDa/38kDa, 41-48kDa |
| 観察された分子量: | 46kDa/60kDa |
| 同義語: | ZBP1, C20orf183, DAI, DLM-1, DLM1 |
| バックグラウンド: | This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 20q13.31 Cellular Component: cytoplasm; nucleus; cytosol Molecular Function:double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; RNA binding Biological Process: metabolic process; positive regulation of interferon type I production; innate immune response |
| NCBI Summary: | This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9H171 |
| NCBI GenInfo Identifier: | 71153189 |
| NCBI Gene ID: | 81030 |
| NCBI Accession: | Q9H171.2 |
| UniProt Secondary Accession: | Q9H171,Q5JY39, Q9BYW4, A2A2F7, B3KVA1, F5GYT1, |
| UniProt Related Accession: | Q9H171 |
| Molecular Weight: | 429 |
| NCBI Full Name: | Z-DNA-binding protein 1 |
| NCBI Synonym Full Names: | Z-DNA binding protein 1 |
| NCBI Official Symbol: | ZBP1 |
| NCBI Official Synonym Symbols: | DAI; DLM1; DLM-1; C20orf183 |
| NCBI Protein Information: | Z-DNA-binding protein 1; DNA-dependent activator of IRFs; DNA-dependent activator of IFN-regulatory factors; tumor stroma and activated macrophage protein DLM-1; DNA-dependent activator of interferon regulatory factors |
| UniProt Protein Name: | Z-DNA-binding protein 1 |
| UniProt Synonym Protein Names: | Tumor stroma and activated macrophage protein DLM-1 |
| Protein Family: | Z-DNA-binding protein |
| UniProt Gene Name: | ZBP1 |
| UniProt Entry Name: | ZBP1_HUMAN |
 | Western blot analysis of extracts of various cell line, using ZBP1 antibody (CAB13899) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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