Anti-XRCC2 Antibody (CAB1800)
- SKU:
- CAB1800
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-XRCC2 Antibody |
| 抗体コード: | CAB1800 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human XRCC2 (NP_005422.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | HeLa, K-562, 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human XRCC2 (NP_005422.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MCSA FHRA ESGT ELLA RLEG RSSL KEIE PNLF ADED SPVH GDIL EFHG PEGT GKTE MLYH LTAR CILP KSEG GLEV EVLF IDTD YHFD MLRL VTIL EHRL SQSS EEII KYCL GRFF LVYC SSST HLLL TLYS LESM FCSH PSLC LLIL DSLS AFYW IDRV NGGE SVNL QEST LRKC SQCL EKLV NDYR LVLF ATTQ TIMQ KASS SSEE PSHA SRRL CDVD IDYR PYLC KAWQ QLVK HRMF FSKQ DDSQ SSNQ FSLV SRCL KSNS LKKH FFII GESG VEFC |
| 遺伝子ID: | 7516 |
| Uniprot: | O43543 |
| セルラーロケーション: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 31kDa |
| 観察された分子量: | 37kDa |
| 同義語: | XRCC2, FANCU |
| バックグラウンド: | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. |
| UniProt Protein Function: | XRCC2: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Belongs to the RecA family. RAD51 subfamily. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 7q36.1 Cellular Component: centrosome; nucleoplasm; replication fork Molecular Function:DNA-dependent ATPase activity; double-stranded DNA binding; endodeoxyribonuclease activity; four-way junction DNA binding; protein binding; recombinase activity; single-stranded DNA binding Biological Process: centrosome organization and biogenesis; DNA repair; DNA synthesis during DNA repair; double-strand break repair via homologous recombination; meiosis; meiotic DNA recombinase assembly; meiotic recombination; mitotic cell cycle; mitotic recombination; response to ionizing radiation; strand displacement; strand invasion |
| NCBI Summary: | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43543 |
| NCBI GenInfo Identifier: | 20140429 |
| NCBI Gene ID: | 7516 |
| NCBI Accession: | O43543.1 |
| UniProt Secondary Accession: | O43543,B2R925, |
| UniProt Related Accession: | O43543 |
| Molecular Weight: | 31,956 Da |
| NCBI Full Name: | DNA repair protein XRCC2 |
| NCBI Synonym Full Names: | X-ray repair cross complementing 2 |
| NCBI Official Symbol: | XRCC2 |
| NCBI Official Synonym Symbols: | FANCU |
| NCBI Protein Information: | DNA repair protein XRCC2 |
| UniProt Protein Name: | DNA repair protein XRCC2 |
| UniProt Synonym Protein Names: | X-ray repair cross-complementing protein 2 |
| Protein Family: | DNA repair protein |
| UniProt Gene Name: | XRCC2 |
| UniProt Entry Name: | XRCC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using XRCC2 antibody (CAB1800) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human thyroid cancer using XRCC2 antibody (CAB1800) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of MCF-7 cells using XRCC2 antibody (CAB1800). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of A549 cells using XRCC2 antibody (CAB1800). |
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