Anti-XRCC1 Antibody (CAB4135)
- SKU:
- CAB4135
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-XRCC1 Antibody |
| 抗体コード: | CAB4135 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human XRCC1 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | K-562, Mouse testis, Rat testis |
| 免疫原: | A synthesized peptide derived from human XRCC1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 7515 |
| Uniprot: | P18887 |
| セルラーロケーション: | |
| 計算された分子量: | 90kDa |
| 観察された分子量: | 82KDa |
| 同義語: | RCC |
| バックグラウンド: | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. |
| UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 19q13.2 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; enzyme binding; damaged DNA binding Biological Process: single strand break repair; base-excision repair; DNA repair |
| NCBI Summary: | The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18887 |
| NCBI GenInfo Identifier: | 317373290 |
| NCBI Gene ID: | 7515 |
| NCBI Accession: | P18887.2 |
| UniProt Secondary Accession: | P18887,Q6IBS4, Q9HCB1, |
| UniProt Related Accession: | P18887 |
| Molecular Weight: | 69,477 Da |
| NCBI Full Name: | DNA repair protein XRCC1 |
| NCBI Synonym Full Names: | X-ray repair complementing defective repair in Chinese hamster cells 1 |
| NCBI Official Symbol: | XRCC1 |
| NCBI Official Synonym Symbols: | RCC |
| NCBI Protein Information: | DNA repair protein XRCC1; X-ray repair cross-complementing protein 1 |
| UniProt Protein Name: | DNA repair protein XRCC1 |
| UniProt Synonym Protein Names: | X-ray repair cross-complementing protein 1 |
| Protein Family: | DNA repair protein |
| UniProt Gene Name: | XRCC1 |
| UniProt Entry Name: | XRCC1_HUMAN |
 | Western blot - XRCC1 Rabbit mAb (CAB4135) |
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